Structural characterization of viral fusion proteins

Research output: Contribution to journalArticlepeer-review

97 Scopus citations

Abstract

Infection by enveloped viruses is initiated by the fusion of viral and cellular membranes. In many cases, the viral membrane proteins that mediate fusion must undergo conformational changes to become active. Influenza hemagglutinin, for example, is activated by a dramatic conformational rearrangement, triggered by the low pH of the intracellular compartment in which fusion occurs. Structural characterization of this rearrangement has led to a reconsideration of how hemagglutinin mediates membrane fusion.

Original languageEnglish (US)
Pages (from-to)265-274
Number of pages10
JournalCurrent Biology
Volume5
Issue number3
DOIs
StatePublished - Mar 1995

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Fingerprint Dive into the research topics of 'Structural characterization of viral fusion proteins'. Together they form a unique fingerprint.

Cite this