Structural characterization of viral fusion proteins

Frederick M. Hughson

doi:10.1016/S0960-9822(95)00057-1

Structural characterization of viral fusion proteins

Frederick M. Hughson

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Abstract

Infection by enveloped viruses is initiated by the fusion of viral and cellular membranes. In many cases, the viral membrane proteins that mediate fusion must undergo conformational changes to become active. Influenza hemagglutinin, for example, is activated by a dramatic conformational rearrangement, triggered by the low pH of the intracellular compartment in which fusion occurs. Structural characterization of this rearrangement has led to a reconsideration of how hemagglutinin mediates membrane fusion.

Original language	English (US)
Pages (from-to)	265-274
Number of pages	10
Journal	Current Biology
Volume	5
Issue number	3
DOIs	https://doi.org/10.1016/S0960-9822(95)00057-1
State	Published - Mar 1995

All Science Journal Classification (ASJC) codes

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)

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10.1016/S0960-9822(95)00057-1

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title = "Structural characterization of viral fusion proteins",

abstract = "Infection by enveloped viruses is initiated by the fusion of viral and cellular membranes. In many cases, the viral membrane proteins that mediate fusion must undergo conformational changes to become active. Influenza hemagglutinin, for example, is activated by a dramatic conformational rearrangement, triggered by the low pH of the intracellular compartment in which fusion occurs. Structural characterization of this rearrangement has led to a reconsideration of how hemagglutinin mediates membrane fusion.",

author = "Hughson, {Frederick M.}",

note = "Funding Information: The author{\textquoteright}s work described in this review was carried out in collaboration with Per A. Bullough, John J. Skehel and Don C. Wiley. In addition, I thank Chave Carr, Senyon Choe, Alan Jasanoff, Peter Kim, Felix Rey, Jim Rothman, Dave Steinhauer, Stan Watowich, and Judy White for stimulating discussions. I am particularly grateful to Don Wiley, John Skehel, Judy White, and Liz Gavis for critical advice about the manuscript and to Stan Watowich for the concept behind Figure 2 . I acknowledge the support of the Helen Hay Whitney foundation and the Howard Hughes Medical Institute. ",

year = "1995",

month = mar,

doi = "10.1016/S0960-9822(95)00057-1",

language = "English (US)",

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pages = "265--274",

journal = "Current Biology",

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AU - Hughson, Frederick M.

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PY - 1995/3

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N2 - Infection by enveloped viruses is initiated by the fusion of viral and cellular membranes. In many cases, the viral membrane proteins that mediate fusion must undergo conformational changes to become active. Influenza hemagglutinin, for example, is activated by a dramatic conformational rearrangement, triggered by the low pH of the intracellular compartment in which fusion occurs. Structural characterization of this rearrangement has led to a reconsideration of how hemagglutinin mediates membrane fusion.

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Structural characterization of viral fusion proteins

Abstract

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