Structural Biology of the Major Facilitator Superfamily Transporters

Nieng Yan

Research output: Contribution to journalArticlepeer-review

312 Scopus citations


The ancient and ubiquitous major facilitator superfamily (MFS) represents the largest secondary transporter family and plays a crucial role in a multitude of physiological processes. MFS proteins transport a broad spectrum of ions and solutes across membranes via facilitated diffusion, symport, or antiport. In recent years, remarkable advances in understanding the structural biology of the MFS transporters have been made. This article reviews the history, classification, and general features of the MFS proteins; summarizes recent structural progress with a focus on the sugar porter family transporters exemplified by GLUT1; and discusses the molecular mechanisms of substrate binding, alternating access, and cotransport coupling.

Original languageEnglish (US)
Pages (from-to)257-283
Number of pages27
JournalAnnual Review of Biophysics
StatePublished - Jun 22 2015

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biophysics
  • Structural Biology
  • Biochemistry
  • Cell Biology


  • Alternating access
  • GLUT1
  • MFS
  • Major facilitator superfamily
  • Membrane transport


Dive into the research topics of 'Structural Biology of the Major Facilitator Superfamily Transporters'. Together they form a unique fingerprint.

Cite this