@article{fa8931fc922a400b9116b3eb03a50e04,
title = "Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2",
abstract = "Structural analyses of NPC1 and its complex with NPC2 reveal the basis for low-pH-dependent cholesterol delivery from the lysosomal lumen to the membrane and provide insights into the effects of more than 200 mutations associated with Niemann-Pick disease type C.",
keywords = "NPC1, NPC2, Niemann-Pick disease type C, cholesterol transport, cryo-EM, lysosomal cholesterol egress, structural biology",
author = "Hongwu Qian and Xuelan Wu and Ximing Du and Xia Yao and Xin Zhao and Joyce Lee and Hongyuan Yang and Nieng Yan",
note = "Funding Information: We thank the cryo-EM facility at Princeton Imaging and Analysis Center, which is partially supported by the Princeton Center for Complex Materials, a National Science Foundation (NSF)-MRSEC program ( DMR-1420541 ). This work was supported in part by the Ara Parseghian Medical Research Foundation (to N.Y. and H.Y.). H.Q. is supported by the New Jersey Council for Cancer Research . H.Y. is supported by the National Health and Medical Research Council, Australia ( 1141939 ). N.Y. is supported by the Innovation Fund for New Ideas in the Natural Sciences , SEAS Innovation Research Grant, and the Shirley M. Tilghman endowed professorship from Princeton University . Publisher Copyright: {\textcopyright} 2020",
year = "2020",
month = jul,
day = "9",
doi = "10.1016/j.cell.2020.05.020",
language = "English (US)",
volume = "182",
pages = "98--111.e18",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "1",
}