@article{7e21b707546c4360908e3aad9dbf005e,
title = "Structural aspects of the glucose and monocarboxylate transporters involved in the Warburg effect",
abstract = "Cancer cells shift their glucose catabolism from aerobic respiration to lactic fermentation even in the presence of oxygen, and this is known as the “Warburg effect”. To accommodate the high glucose demands and to avoid lactate accumulation, the expression levels of human glucose transporters (GLUTs) and human monocarboxylate transporters (MCTs) are elevated to maintain metabolic homeostasis. Therefore, inhibition of GLUTs and/or MCTs provides potential therapeutic strategies for cancer treatment. Here, we summarize recent advances in the structural characterization of GLUTs and MCTs, providing a comprehensive understanding of their transport and inhibition mechanisms to facilitate further development of anticancer therapies.",
keywords = "Warburg effect, alternating access, glucose transporters, lactate shuttling, monocarboxylate transporters",
author = "Xin Jiang and Nieng Yan and Dong Deng and Chuangye Yan",
note = "Funding Information: This work was funded by the National Key R and D Program of China (2020YFA0509301, Chuangye Yan), Beijing Nova Program (Z201100006820039, Chuangye Yan), Beijing Frontier Research Center for Biological Structure, Beijing Advanced Innovation Center for Structural Biology, and Start-up funds from Tsinghua-Peking Center for Life Sciences and Tsinghua University. Funding Information: Beijing Nova Program, Grant/Award Number: Z201100006820039; the National Key R&D Program of China, Grant/Award Number: 2020YFA0509301; Tsinghua‐Peking Center for Life Sciences and Tsinghua University Funding information Funding Information: This work was funded by the National Key R and D Program of China (2020YFA0509301, Chuangye Yan), Beijing Nova Program (Z201100006820039, Chuangye Yan), Beijing Frontier Research Center for Biological Structure, Beijing Advanced Innovation Center for Structural Biology, and Start‐up funds from Tsinghua‐Peking Center for Life Sciences and Tsinghua University. Publisher Copyright: {\textcopyright} 2022 International Union of Biochemistry and Molecular Biology.",
year = "2022",
month = dec,
doi = "10.1002/iub.2668",
language = "English (US)",
volume = "74",
pages = "1180--1199",
journal = "Biochemistry and Molecular Biology International",
issn = "1521-6543",
publisher = "Wiley-Blackwell",
number = "12",
}