TY - JOUR
T1 - Structural advances for the major facilitator superfamily (MFS) transporters
AU - Yan, Nieng
N1 - Funding Information:
This work was supported by funds from the Ministry of Science and Technology (grant numbers 2009CB918802 and 2011CB910501), Projects 31125009 and 91017011 of the National Natural Science Foundation of China, and funds from Tsinghua University. The research of N.Y. was supported in part by an International Early Career Scientist grant from the Howard Hughes Medical Institute.
PY - 2013/3
Y1 - 2013/3
N2 - The major facilitator superfamily (MFS) is one of the largest groups of secondary active transporters conserved from bacteria to humans. MFS proteins selectively transport a wide spectrum of substrates across biomembranes and play a pivotal role in multiple physiological processes. Despite intense investigation, only seven MFS proteins from six subfamilies have been structurally elucidated. These structures were captured in distinct states during a transport cycle involving alternating access to binding sites from either side of the membrane. This review discusses recent progress in MFS structure analysis and focuses on the molecular basis for substrate binding, co-transport coupling, and alternating access.
AB - The major facilitator superfamily (MFS) is one of the largest groups of secondary active transporters conserved from bacteria to humans. MFS proteins selectively transport a wide spectrum of substrates across biomembranes and play a pivotal role in multiple physiological processes. Despite intense investigation, only seven MFS proteins from six subfamilies have been structurally elucidated. These structures were captured in distinct states during a transport cycle involving alternating access to binding sites from either side of the membrane. This review discusses recent progress in MFS structure analysis and focuses on the molecular basis for substrate binding, co-transport coupling, and alternating access.
KW - 3-TM (transmembrane segments) repeat
KW - Alternating access
KW - Major facilitator superfamily
KW - Structure
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U2 - 10.1016/j.tibs.2013.01.003
DO - 10.1016/j.tibs.2013.01.003
M3 - Review article
C2 - 23403214
AN - SCOPUS:84874258738
SN - 0968-0004
VL - 38
SP - 151
EP - 159
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 3
ER -