Stress and adult neurogenesis

Christian Mirescu, Elizabeth Gould

Research output: Contribution to journalReview article

490 Scopus citations

Abstract

Stress hormones have potent growth-inhibiting effects on a variety of peripheral tissues. Consistent with this general function, stress has been shown to inhibit cell proliferation and, ultimately, neurogenesis in the hippocampus. This effect appears to be common across mammalian species, life stages, and most types of stressors. Although some evidence points to a role for glucocorticoids in mediating this effect, contradictory data exist. This review considers the growing literature on this subject with specific emphasis on paradoxical findings and the role of glucocorticoids in modulating adult neurogenesis.

Original languageEnglish (US)
Pages (from-to)233-238
Number of pages6
JournalHippocampus
Volume16
Issue number3
DOIs
StatePublished - Mar 28 2006

All Science Journal Classification (ASJC) codes

  • Cognitive Neuroscience

Keywords

  • Dentate gyrus
  • Glucocorticoids
  • Hippocampus
  • Neurogenesis
  • Stress

Fingerprint Dive into the research topics of 'Stress and adult neurogenesis'. Together they form a unique fingerprint.

  • Cite this