Stoichiometry Controls the Dynamics of Liquid Condensates of Associative Proteins

Pierre Ronceray, Yaojun Zhang, Xichong Liu, Ned S. Wingreen

Research output: Contribution to journalArticlepeer-review

Abstract

Multivalent associative proteins with strong complementary interactions play a crucial role in phase separation of intracellular liquid condensates. We study the internal dynamics of such "bond-network"condensates comprising two complementary proteins via scaling analysis and molecular dynamics. We find that when stoichiometry is balanced, relaxation slows down dramatically due to a scarcity of alternative binding partners following bond breakage. This microscopic slow-down strongly affects the bulk diffusivity, viscosity, and mixing, which provides a means to experimentally test this prediction.

Original languageEnglish (US)
Article numberA82
JournalPhysical review letters
Volume128
Issue number3
DOIs
StatePublished - Jan 21 2022

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

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