@article{fe9c2661e3004836a998604a0f2c92a6,
title = "Stoichiometry Controls the Dynamics of Liquid Condensates of Associative Proteins",
abstract = "Multivalent associative proteins with strong complementary interactions play a crucial role in phase separation of intracellular liquid condensates. We study the internal dynamics of such {"}bond-network{"}condensates comprising two complementary proteins via scaling analysis and molecular dynamics. We find that when stoichiometry is balanced, relaxation slows down dramatically due to a scarcity of alternative binding partners following bond breakage. This microscopic slow-down strongly affects the bulk diffusivity, viscosity, and mixing, which provides a means to experimentally test this prediction.",
author = "Pierre Ronceray and Yaojun Zhang and Xichong Liu and Wingreen, {Ned S.}",
note = "Funding Information: This work was supported by the NSF, through the Center for the Physics of Biological Function (PHY-1734030), by NIH Grant No. R01 GM140032 (N. S. W.), by The Susan and John Diekman {\textquoteright}65 Genomics Faculty Support Fund through the Lewis-Sigler Institute of Integrative Genomics at Princeton University, and by the Princeton Biomolecular Condensate Program. P. R. is supported by the “Investissements d{\textquoteright}Avenir” French Government program managed by the French National Research Agency (ANR-16-CONV-0001) and by the Excellence Initiative of Aix-Marseille University–A*MIDEX. Publisher Copyright: {\textcopyright} 2022 American Physical Society.",
year = "2022",
month = jan,
day = "21",
doi = "10.1103/PhysRevLett.128.038102",
language = "English (US)",
volume = "128",
journal = "Physical review letters",
issn = "0031-9007",
publisher = "American Physical Society",
number = "3",
}