Stereoselective synthesis from a process research perspective

Michael C. Hillier, Paul J. Reider

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


The process chemists' primary responsibility is to develop efficient and reproducible syntheses of pharmaceutically active compounds. This task is complicated when dealing with chiral molecules that often must be made as single isomers according to regulatory guidelines. The presence of any isomeric impurity in the final product, even in small amounts, is usually not acceptable. This requirement necessitates an exquisite understanding of the methods employed in the construction of chiral drugs. However, the chemistry available for this purpose is sometimes limited and often requires a significant amount of effort and creativity to be made both functional and consistent.

Original languageEnglish (US)
Pages (from-to)303-314
Number of pages12
JournalDrug Discovery Today
Issue number5
StatePublished - Mar 1 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Pharmacology


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