Stereoselective hydrogen bromide-promoted hydrogenation of an α-hydroxyoxime

I. W. Davies, M. Taylor, J. F. Marcoux, L. Matty, J. Wu, D. Hughes, P. J. Reider

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Hydrogen bromide has been demonstrated to provide optimal cis-selectivity in the reduction of 4-chromanone α-hydroxyoxime (25:1 cis/trans) in 94% yield. This reaction is pivotal in the synthesis of cis-aminochromanol. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)8021-8025
Number of pages5
JournalTetrahedron Letters
Issue number42
StatePublished - Oct 14 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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