Hydrogen bromide has been demonstrated to provide optimal cis-selectivity in the reduction of 4-chromanone α-hydroxyoxime (25:1 cis/trans) in 94% yield. This reaction is pivotal in the synthesis of cis-aminochromanol. (C) 2000 Elsevier Science Ltd.
|Original language||English (US)|
|Number of pages||5|
|State||Published - Oct 14 2000|
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry