Statics and dynamics of single DNA molecules confined in nanochannels

Walter Reisner, Keith J. Morton, Robert Riehn, Yan Mei Wang, Zhaoning Yu, Michael Rosen, James C. Sturm, Stephen Y. Chou, Erwin Frey, Robert H. Austin

Research output: Contribution to journalArticle

438 Scopus citations

Abstract

The successful design of nanofluidic devices for the manipulation of biopolymers requires an understanding of how the predictions of soft condensed matter physics scale with device dimensions. Here we present measurements of DNA extended in nanochannels and show that below a critical width roughly twice the persistence length there is a crossover in the polymer physics.

Original languageEnglish (US)
Article number196101
JournalPhysical review letters
Volume94
Issue number19
DOIs
StatePublished - May 20 2005

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

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