@article{ef0fd0f25dad4acd8fbf803ba107897f,
title = "Static to inducibly dynamic stereocontrol: The convergent use of racemic b-substituted ketones",
abstract = "The synthesis of stereochemically complex molecules in the pharmaceutical and agrochemical industries requires precise control over each distinct stereocenter, a feat that can be challenging and time consuming using traditional asymmetric synthesis. Although stereoconvergent processes have the potential to streamline and simplify synthetic routes, they are currently limited by a narrow scope of inducibly dynamic stereocenters that can be readily epimerized. Here, we report the use of photoredox catalysis to enable the racemization of traditionally static, unreactive stereocenters through the intermediacy of prochiral radical species. This technology was applied in conjunction with biocatalysts such as ketoreductases and aminotransferases to realize stereoconvergent syntheses of stereodefined g-substituted alcohols and amines from b-substituted ketones.",
author = "DeHovitz, {Jacob S.} and Loh, {Yong Yao} and Kautzky, {Jacob A.} and Kazunori Nagao and Meichan, {Andrew J.} and Motoshi Yamauchi and MacMillan, {David W.C.} and Hyster, {Todd K.}",
note = "Funding Information: We thank Codexis and Prozomix for providing transaminases and ketoreductases, respectively. We also thank V. Bacauanu, B. X. Li, and D. K. Kim for their assistance with the preparation of this manuscript, and P. Jeffery for assistance with x-ray structure determination. Research reported in this publication was supported by BioLEC, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, under award DE-SC0019370, and the Princeton Catalysis Initiative. The authors also acknowledge funding from Merck, Bristol-Myers Squibb (BMS), Eli Lilly, Genentech, Pfizer, and Johnson & Johnson. T.K.H. is supported by a Searle Scholars Award (SSP-2017-1741), a Sloan Research Fellowship, and the ACS-PRF. J.S.D. and Y.Y.L. are supported by BMS graduate fellowships. Y.Y.L. is also supported by an A*STAR graduate fellowship. J.A.K. is supported by a NSF GRFP (DGE 1656466) predoctoral fellowship. K.N. is supported by a JSPS overseas postdoctoral fellowship. M.Y. received funding from Daiichi Sankyo Co., Ltd. Publisher Copyright: Copyright {\textcopyright} 2020 The Authors,",
year = "2020",
month = aug,
day = "28",
doi = "10.1126/science.abc9909",
language = "English (US)",
volume = "369",
pages = "1113--1118",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6507",
}