Stable long-term chronic brain mapping at the single-neuron level

Tian Ming Fu, Guosong Hong, Tao Zhou, Thomas G. Schuhmann, Robert D. Viveros, Charles M. Lieber

Research output: Contribution to journalArticlepeer-review

172 Scopus citations

Abstract

Stable in vivo mapping and modulation of the same neurons and brain circuits over extended periods is critical to both neuroscience and medicine. Current electrical implants offer single-neuron spatiotemporal resolution but are limited by such factors as relative shear motion and chronic immune responses during long-term recording. To overcome these limitations, we developed a chronic in vivo recording and stimulation platform based on flexible mesh electronics, and we demonstrated stable multiplexed local field potentials and single-unit recordings in mouse brains for at least 8 months without probe repositioning. Properties of acquired signals suggest robust tracking of the same neurons over this period. This recording and stimulation platform allowed us to evoke stable single-neuron responses to chronic electrical stimulation and to carry out longitudinal studies of brain aging in freely behaving mice. Such advantages could open up future studies in mapping and modulating changes associated with learning, aging and neurodegenerative diseases.

Original languageEnglish (US)
Pages (from-to)875-882
Number of pages8
JournalNature Methods
Volume13
Issue number10
DOIs
StatePublished - Oct 1 2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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