Stabilization of phosphatidylserine/phosphatidylethanolamine liposomes with hydrophilic polymers having multiple "sticky feet"

Melinda L. Hwang, Robert K. Prud'homme, Joachim Kohn, James L. Thomas

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

The ability of three novel polymers to protect phosphatidylethanolamine/phosphatidylserine (1:1) vesicles against calcium-induced destabilization (dye leakage) has been investigated. The polymers are a telechelic, hydrophobically terminated poly(ethylene glycol) (PEG), a polymer of the macromonomer PEG8000-lysine-stearylamide, and a hydrophobically modified poly(acrylic acid). These polymers are predominantly hydrophilic but have multiple hydrophobic moieties which serve to anchor them in the lipid bilayers. Like singly anchored PEG, the two PEG-based polymers were able to provide effective stabilization at concentrations sufficient to produce a polymer "brush" on the liposome surface. Interestingly, the poly(acrylic acid) polymer did not provide full stabilization even at concentrations that should have produced brush coverage, possibly owing to a more expanded polymer conformation. The potential advantages of stabilization with polymers having multiple "sticky feet" are discussed.

Original languageEnglish (US)
Pages (from-to)7713-7716
Number of pages4
JournalLangmuir
Volume17
Issue number25
DOIs
StatePublished - Dec 11 2001

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

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