Stability and noise in biochemical switches

Research output: Chapter in Book/Report/Conference proceedingConference contribution

34 Scopus citations

Abstract

Many processes in biology, from the regulation of gene expression in bacteria to memory in the brain, involve switches constructed from networks of biochemical reactions. Crucial molecules are present in small numbers, raising questions about noise and stability. Analysis of noise in simple reaction schemes indicates that switches stable for years and switchable in milliseconds can be built from fewer than one hundred molecules. Prospects for direct tests of this prediction, as well as implications, are discussed.

Original languageEnglish (US)
Title of host publicationAdvances in Neural Information Processing Systems 13 - Proceedings of the 2000 Conference, NIPS 2000
PublisherNeural information processing systems foundation
ISBN (Print)0262122413, 9780262122412
StatePublished - Jan 1 2001
Event14th Annual Neural Information Processing Systems Conference, NIPS 2000 - Denver, CO, United States
Duration: Nov 27 2000Dec 2 2000

Other

Other14th Annual Neural Information Processing Systems Conference, NIPS 2000
CountryUnited States
CityDenver, CO
Period11/27/0012/2/00

All Science Journal Classification (ASJC) codes

  • Computer Networks and Communications
  • Information Systems
  • Signal Processing

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    Bialek, W. (2001). Stability and noise in biochemical switches. In Advances in Neural Information Processing Systems 13 - Proceedings of the 2000 Conference, NIPS 2000 Neural information processing systems foundation.