TY - GEN
T1 - Stability and noise in biochemical switches
AU - Bialek, William
PY - 2001
Y1 - 2001
N2 - Many processes in biology, from the regulation of gene expression in bacteria to memory in the brain, involve switches constructed from networks of biochemical reactions. Crucial molecules are present in small numbers, raising questions about noise and stability. Analysis of noise in simple reaction schemes indicates that switches stable for years and switchable in milliseconds can be built from fewer than one hundred molecules. Prospects for direct tests of this prediction, as well as implications, are discussed.
AB - Many processes in biology, from the regulation of gene expression in bacteria to memory in the brain, involve switches constructed from networks of biochemical reactions. Crucial molecules are present in small numbers, raising questions about noise and stability. Analysis of noise in simple reaction schemes indicates that switches stable for years and switchable in milliseconds can be built from fewer than one hundred molecules. Prospects for direct tests of this prediction, as well as implications, are discussed.
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UR - http://www.scopus.com/inward/citedby.url?scp=84898965048&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84898965048
SN - 0262122413
SN - 9780262122412
T3 - Advances in Neural Information Processing Systems
BT - Advances in Neural Information Processing Systems 13 - Proceedings of the 2000 Conference, NIPS 2000
PB - Neural information processing systems foundation
T2 - 14th Annual Neural Information Processing Systems Conference, NIPS 2000
Y2 - 27 November 2000 through 2 December 2000
ER -