TY - JOUR
T1 - SprE levels are growth phase regulated in a σ(S)-dependent manner at the level of translation
AU - Gibson, Katherine E.
AU - Silhavy, Thomas J.
PY - 2000/7
Y1 - 2000/7
N2 - SprE regulates σ(S) levels in response to nutrient availability by promoting ClpXP-mediated degradation. Paradoxically, we observe that SprE is similarly regulated, accumulating preferentially upon starvation. This regulation of SprE levels is σ(S) dependent, altering SprE synthesis at the level of translation. Thus, we demonstrate that SprE and σ(S) function within a regulatory feedback loop.
AB - SprE regulates σ(S) levels in response to nutrient availability by promoting ClpXP-mediated degradation. Paradoxically, we observe that SprE is similarly regulated, accumulating preferentially upon starvation. This regulation of SprE levels is σ(S) dependent, altering SprE synthesis at the level of translation. Thus, we demonstrate that SprE and σ(S) function within a regulatory feedback loop.
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U2 - 10.1128/JB.182.14.4117-4120.2000
DO - 10.1128/JB.182.14.4117-4120.2000
M3 - Article
C2 - 10869095
AN - SCOPUS:0033917869
SN - 0021-9193
VL - 182
SP - 4117
EP - 4120
JO - Journal of bacteriology
JF - Journal of bacteriology
IS - 14
ER -