SprE levels are growth phase regulated in a σ(S)-dependent manner at the level of translation

Katherine E. Gibson, Thomas J. Silhavy

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

SprE regulates σ(S) levels in response to nutrient availability by promoting ClpXP-mediated degradation. Paradoxically, we observe that SprE is similarly regulated, accumulating preferentially upon starvation. This regulation of SprE levels is σ(S) dependent, altering SprE synthesis at the level of translation. Thus, we demonstrate that SprE and σ(S) function within a regulatory feedback loop.

Original languageEnglish (US)
Pages (from-to)4117-4120
Number of pages4
JournalJournal of bacteriology
Volume182
Issue number14
DOIs
StatePublished - Jul 2000

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Biology

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