Specific T cell recognition of kinetic isomers in the binding of peptide to class II major histocompatibility complex

Joshua D. Rabinowitz, Michael N. Liang, Keri Tate, Christopher Lee, Craig Beeson, Harden M. Mcconnell

Research output: Contribution to journalArticle

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Abstract

Helper T cells are triggered by molecular complexes of antigenic peptides and class II proteins of the major histocompatibility complex. The formation of stable complexes between class II major histocompatibility complex proteins and antigenic peptides is often accompanied by the formation of a short-lived complex. In this report, we describe T cell recognition of two distinct complexes, one short-lived and the other long-lived, formed during the binding of an altered myelin basic protein peptide to I-A(k). One myelin basic protein-specific T cell clone is triggered by only the short- lived complex, and another is triggered by only the stable complex. Thus, a single peptide bound to a particular class II molecule can activate different T cells depending on the conditions of the binding reaction.

Original languageEnglish (US)
Pages (from-to)8702-8707
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume94
Issue number16
DOIs
StatePublished - Aug 5 1997

All Science Journal Classification (ASJC) codes

  • General

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