TY - JOUR
T1 - Specific T cell recognition of kinetic isomers in the binding of peptide to class II major histocompatibility complex
AU - Rabinowitz, Joshua D.
AU - Liang, Michael N.
AU - Tate, Keri
AU - Lee, Christopher
AU - Beeson, Craig
AU - Mcconnell, Harden M.
PY - 1997/8/5
Y1 - 1997/8/5
N2 - Helper T cells are triggered by molecular complexes of antigenic peptides and class II proteins of the major histocompatibility complex. The formation of stable complexes between class II major histocompatibility complex proteins and antigenic peptides is often accompanied by the formation of a short-lived complex. In this report, we describe T cell recognition of two distinct complexes, one short-lived and the other long-lived, formed during the binding of an altered myelin basic protein peptide to I-A(k). One myelin basic protein-specific T cell clone is triggered by only the short- lived complex, and another is triggered by only the stable complex. Thus, a single peptide bound to a particular class II molecule can activate different T cells depending on the conditions of the binding reaction.
AB - Helper T cells are triggered by molecular complexes of antigenic peptides and class II proteins of the major histocompatibility complex. The formation of stable complexes between class II major histocompatibility complex proteins and antigenic peptides is often accompanied by the formation of a short-lived complex. In this report, we describe T cell recognition of two distinct complexes, one short-lived and the other long-lived, formed during the binding of an altered myelin basic protein peptide to I-A(k). One myelin basic protein-specific T cell clone is triggered by only the short- lived complex, and another is triggered by only the stable complex. Thus, a single peptide bound to a particular class II molecule can activate different T cells depending on the conditions of the binding reaction.
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U2 - 10.1073/pnas.94.16.8702
DO - 10.1073/pnas.94.16.8702
M3 - Article
C2 - 9238041
AN - SCOPUS:0030833638
SN - 0027-8424
VL - 94
SP - 8702
EP - 8707
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 16
ER -