Spatially regulated expression of homeotic genes in Drosophila

Katherine Harding; Cathy Wedeen; William McGinnis; Michael Levine

doi:10.1126/science.3898362

Spatially regulated expression of homeotic genes in Drosophila

Katherine Harding, Cathy Wedeen, William McGinnis, Michael Levine

Research output: Contribution to journal › Article › peer-review

173 Scopus citations

Abstract

The sites of transcript accumulation for six different homeotic loci of the Antennapedia and bithorax gene complexes (ANT-C and BX-C) were identified within embryo tissue sections by in situ hybridization. These six loci belong to the Antennapedia class of the homeo box gene family. Transcripts encoded by each locus are detected primarily in discrete, nonoverlapping regions of the embryonic central nervous system (CNS). The regions of the CNS that contain transcripts encoded by each of these loci correspond to the embryonic segments that are disrupted in mutants for these genes. The maintenance of spatially restricted expression of each ANT-C and BX-C locus could involve hierarchical, cross-regulatory interactions that are mediated by the homeo box protein domains encoded by these genes.

Original language	English (US)
Pages (from-to)	1236-1242
Number of pages	7
Journal	Science
Volume	229
Issue number	4719
DOIs	https://doi.org/10.1126/science.3898362
State	Published - 1985
Externally published	Yes

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10.1126/science.3898362

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title = "Spatially regulated expression of homeotic genes in Drosophila",

abstract = "The sites of transcript accumulation for six different homeotic loci of the Antennapedia and bithorax gene complexes (ANT-C and BX-C) were identified within embryo tissue sections by in situ hybridization. These six loci belong to the Antennapedia class of the homeo box gene family. Transcripts encoded by each locus are detected primarily in discrete, nonoverlapping regions of the embryonic central nervous system (CNS). The regions of the CNS that contain transcripts encoded by each of these loci correspond to the embryonic segments that are disrupted in mutants for these genes. The maintenance of spatially restricted expression of each ANT-C and BX-C locus could involve hierarchical, cross-regulatory interactions that are mediated by the homeo box protein domains encoded by these genes.",

author = "Katherine Harding and Cathy Wedeen and William McGinnis and Michael Levine",

year = "1985",

doi = "10.1126/science.3898362",

language = "English (US)",

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journal = "Science",

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publisher = "American Association for the Advancement of Science",

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T1 - Spatially regulated expression of homeotic genes in Drosophila

AU - Harding, Katherine

AU - Wedeen, Cathy

AU - McGinnis, William

AU - Levine, Michael

PY - 1985

Y1 - 1985

N2 - The sites of transcript accumulation for six different homeotic loci of the Antennapedia and bithorax gene complexes (ANT-C and BX-C) were identified within embryo tissue sections by in situ hybridization. These six loci belong to the Antennapedia class of the homeo box gene family. Transcripts encoded by each locus are detected primarily in discrete, nonoverlapping regions of the embryonic central nervous system (CNS). The regions of the CNS that contain transcripts encoded by each of these loci correspond to the embryonic segments that are disrupted in mutants for these genes. The maintenance of spatially restricted expression of each ANT-C and BX-C locus could involve hierarchical, cross-regulatory interactions that are mediated by the homeo box protein domains encoded by these genes.

AB - The sites of transcript accumulation for six different homeotic loci of the Antennapedia and bithorax gene complexes (ANT-C and BX-C) were identified within embryo tissue sections by in situ hybridization. These six loci belong to the Antennapedia class of the homeo box gene family. Transcripts encoded by each locus are detected primarily in discrete, nonoverlapping regions of the embryonic central nervous system (CNS). The regions of the CNS that contain transcripts encoded by each of these loci correspond to the embryonic segments that are disrupted in mutants for these genes. The maintenance of spatially restricted expression of each ANT-C and BX-C locus could involve hierarchical, cross-regulatory interactions that are mediated by the homeo box protein domains encoded by these genes.

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Spatially regulated expression of homeotic genes in Drosophila

Abstract

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