Spatially regulated expression of homeotic genes in Drosophila

Katherine Harding, Cathy Wedeen, William McGinnis, Michael Levine

Research output: Contribution to journalArticle

136 Scopus citations

Abstract

The sites of transcript accumulation for six different homeotic loci of the Antennapedia and bithorax gene complexes (ANT-C and BX-C) were identified within embryo tissue sections by in situ hybridization. These six loci belong to the Antennapedia class of the homeo box gene family. Transcripts encoded by each locus are detected primarily in discrete, nonoverlapping regions of the embryonic central nervous system (CNS). The regions of the CNS that contain transcripts encoded by each of these loci correspond to the embryonic segments that are disrupted in mutants for these genes. The maintenance of spatially restricted expression of each ANT-C and BX-C locus could involve hierarchical, cross-regulatory interactions that are mediated by the homeo box protein domains encoded by these genes.

Original languageEnglish (US)
Pages (from-to)1236-1242
Number of pages7
JournalScience
Volume229
Issue number4719
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

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