Spatial regulation of antennapedia and bithorax gene expression by the Polycomb locus in Drosophila

Cathy Wedeen; Katherine Harding; Michael Levine

doi:10.1016/0092-8674(86)90840-8

Spatial regulation of antennapedia and bithorax gene expression by the Polycomb locus in Drosophila

Cathy Wedeen, Katherine Harding, Michael Levine

Research output: Contribution to journal › Article › peer-review

155 Scopus citations

Abstract

Transcripts encoded by six of the homeotic lethal complementation groups within the Antennapedia and bithorax gene complexes (ANT-C and BX-C) accumulate primarily in nonoverlapping regions of the embryonic central nervous system (CNS). It has been previously proposed that the maintenance of these selective patterns of expression involve hierarchical cross-regulatory interactions among ANT-C and BX-C loci. Selective expression of the ANT-C and BX-C also involves regulation by a number of unlinked genetic loci, including the Polycomb (Pc) locus. Here we show that the ANT-C and BX-C transcript distribution patterns are dramatically altered in the CNS of Pc^- embryos. We discuss these altered patterns of expression in the context of different models for the spatial regulation of ANT-C and BX-C gene expression.

Original language	English (US)
Pages (from-to)	739-748
Number of pages	10
Journal	Cell
Volume	44
Issue number	5
DOIs	https://doi.org/10.1016/0092-8674(86)90840-8
State	Published - Mar 14 1986
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology

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10.1016/0092-8674(86)90840-8

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@article{d5f25a94581a456ea460defe0b211f73,

title = "Spatial regulation of antennapedia and bithorax gene expression by the Polycomb locus in Drosophila",

abstract = "Transcripts encoded by six of the homeotic lethal complementation groups within the Antennapedia and bithorax gene complexes (ANT-C and BX-C) accumulate primarily in nonoverlapping regions of the embryonic central nervous system (CNS). It has been previously proposed that the maintenance of these selective patterns of expression involve hierarchical cross-regulatory interactions among ANT-C and BX-C loci. Selective expression of the ANT-C and BX-C also involves regulation by a number of unlinked genetic loci, including the Polycomb (Pc) locus. Here we show that the ANT-C and BX-C transcript distribution patterns are dramatically altered in the CNS of Pc- embryos. We discuss these altered patterns of expression in the context of different models for the spatial regulation of ANT-C and BX-C gene expression.",

author = "Cathy Wedeen and Katherine Harding and Michael Levine",

note = "Funding Information: We wish to thank Bill McGinnis, Eric Frei, Diane Robins, and Markus Noll for suggestions and encouragement. We also thank Bill McGinnis, Eva Dworkin-Rastl, Helen Doyle, and Tim Hoey for critically reviewing the manuscript. We are deeply indebted to E. 6. Lewis for providing fly stocks and the intellectual foundation for this study. We are pleased to express our gratitude to Linda Adler, Madeline Kilminster, Cristina Healey, and Heather von Manowski for preparing the manuscript. This work was supported by grants from the National Institutes of Health and the Searle Scholars Program.",

year = "1986",

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doi = "10.1016/0092-8674(86)90840-8",

language = "English (US)",

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pages = "739--748",

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T1 - Spatial regulation of antennapedia and bithorax gene expression by the Polycomb locus in Drosophila

AU - Wedeen, Cathy

AU - Harding, Katherine

AU - Levine, Michael

N1 - Funding Information: We wish to thank Bill McGinnis, Eric Frei, Diane Robins, and Markus Noll for suggestions and encouragement. We also thank Bill McGinnis, Eva Dworkin-Rastl, Helen Doyle, and Tim Hoey for critically reviewing the manuscript. We are deeply indebted to E. 6. Lewis for providing fly stocks and the intellectual foundation for this study. We are pleased to express our gratitude to Linda Adler, Madeline Kilminster, Cristina Healey, and Heather von Manowski for preparing the manuscript. This work was supported by grants from the National Institutes of Health and the Searle Scholars Program.

PY - 1986/3/14

Y1 - 1986/3/14

N2 - Transcripts encoded by six of the homeotic lethal complementation groups within the Antennapedia and bithorax gene complexes (ANT-C and BX-C) accumulate primarily in nonoverlapping regions of the embryonic central nervous system (CNS). It has been previously proposed that the maintenance of these selective patterns of expression involve hierarchical cross-regulatory interactions among ANT-C and BX-C loci. Selective expression of the ANT-C and BX-C also involves regulation by a number of unlinked genetic loci, including the Polycomb (Pc) locus. Here we show that the ANT-C and BX-C transcript distribution patterns are dramatically altered in the CNS of Pc- embryos. We discuss these altered patterns of expression in the context of different models for the spatial regulation of ANT-C and BX-C gene expression.

AB - Transcripts encoded by six of the homeotic lethal complementation groups within the Antennapedia and bithorax gene complexes (ANT-C and BX-C) accumulate primarily in nonoverlapping regions of the embryonic central nervous system (CNS). It has been previously proposed that the maintenance of these selective patterns of expression involve hierarchical cross-regulatory interactions among ANT-C and BX-C loci. Selective expression of the ANT-C and BX-C also involves regulation by a number of unlinked genetic loci, including the Polycomb (Pc) locus. Here we show that the ANT-C and BX-C transcript distribution patterns are dramatically altered in the CNS of Pc- embryos. We discuss these altered patterns of expression in the context of different models for the spatial regulation of ANT-C and BX-C gene expression.

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JO - Cell

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Spatial regulation of antennapedia and bithorax gene expression by the Polycomb locus in Drosophila

Abstract

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