Spatial regulation of antennapedia and bithorax gene expression by the Polycomb locus in Drosophila

Cathy Wedeen, Katherine Harding, Michael Levine

Research output: Contribution to journalArticle

129 Scopus citations

Abstract

Transcripts encoded by six of the homeotic lethal complementation groups within the Antennapedia and bithorax gene complexes (ANT-C and BX-C) accumulate primarily in nonoverlapping regions of the embryonic central nervous system (CNS). It has been previously proposed that the maintenance of these selective patterns of expression involve hierarchical cross-regulatory interactions among ANT-C and BX-C loci. Selective expression of the ANT-C and BX-C also involves regulation by a number of unlinked genetic loci, including the Polycomb (Pc) locus. Here we show that the ANT-C and BX-C transcript distribution patterns are dramatically altered in the CNS of Pc- embryos. We discuss these altered patterns of expression in the context of different models for the spatial regulation of ANT-C and BX-C gene expression.

Original languageEnglish (US)
Pages (from-to)739-748
Number of pages10
JournalCell
Volume44
Issue number5
DOIs
StatePublished - Mar 14 1986
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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