Sources of diversity in bactobolin biosynthesis by burkholderia thailandensis E264

Gavin Carr; Mohammad R. Seyedsayamdost; Josephine R. Chandler; E. Peter Greenberg; Jon Clardy

doi:10.1021/ol200922s

Sources of diversity in bactobolin biosynthesis by burkholderia thailandensis E264

Gavin Carr, Mohammad R. Seyedsayamdost, Josephine R. Chandler, E. Peter Greenberg, Jon Clardy

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

A series of deletion mutants in the recently identified bactobolin biosynthetic pathway defined the roles of several key biosynthetic enzymes and showed how promiscuity in three enzyme systems allows this cluster to produce multiple products. Studies on the deletion mutants also led to four new bactobolin analogs that provide additional structure-activity relationships for this interesting antibiotic family.

Original language	English (US)
Pages (from-to)	3048-3051
Number of pages	4
Journal	Organic letters
Volume	13
Issue number	12
DOIs	https://doi.org/10.1021/ol200922s
State	Published - Jun 17 2011
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol200922s

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title = "Sources of diversity in bactobolin biosynthesis by burkholderia thailandensis E264",

abstract = "A series of deletion mutants in the recently identified bactobolin biosynthetic pathway defined the roles of several key biosynthetic enzymes and showed how promiscuity in three enzyme systems allows this cluster to produce multiple products. Studies on the deletion mutants also led to four new bactobolin analogs that provide additional structure-activity relationships for this interesting antibiotic family.",

author = "Gavin Carr and Seyedsayamdost, {Mohammad R.} and Chandler, {Josephine R.} and Greenberg, {E. Peter} and Jon Clardy",

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AU - Clardy, Jon

PY - 2011/6/17

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AB - A series of deletion mutants in the recently identified bactobolin biosynthetic pathway defined the roles of several key biosynthetic enzymes and showed how promiscuity in three enzyme systems allows this cluster to produce multiple products. Studies on the deletion mutants also led to four new bactobolin analogs that provide additional structure-activity relationships for this interesting antibiotic family.

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Sources of diversity in bactobolin biosynthesis by burkholderia thailandensis E264

Abstract

All Science Journal Classification (ASJC) codes

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