Sources of diversity in bactobolin biosynthesis by burkholderia thailandensis E264

Gavin Carr, Mohammad R. Seyedsayamdost, Josephine R. Chandler, E. Peter Greenberg, Jon Clardy

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

A series of deletion mutants in the recently identified bactobolin biosynthetic pathway defined the roles of several key biosynthetic enzymes and showed how promiscuity in three enzyme systems allows this cluster to produce multiple products. Studies on the deletion mutants also led to four new bactobolin analogs that provide additional structure-activity relationships for this interesting antibiotic family.

Original languageEnglish (US)
Pages (from-to)3048-3051
Number of pages4
JournalOrganic letters
Volume13
Issue number12
DOIs
StatePublished - Jun 17 2011

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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