In the classic picture of morphogen-mediated patterning, cells acquire the correct spatial arrangement of specified fates by reading a precisely distributed gradient of morphogen. Xiong et al. now provide evidence for an alternate strategy - cells of the zebrafish neural tube actively sort to their correct positions following disordered specification by Sonic hedgehog.
All Science Journal Classification (ASJC) codes
- General Biochemistry, Genetics and Molecular Biology