Solidification of protein aggregates deepens bacterial dormancy

Katherine J. Sniezek; Nashaly Soto-Echevarria; Mark P. Brynildsen

doi:10.1016/j.tim.2025.03.001

Solidification of protein aggregates deepens bacterial dormancy

Katherine J. Sniezek, Nashaly Soto-Echevarria, Mark P. Brynildsen

Research output: Contribution to journal › Short survey › peer-review

Abstract

Bacteria can exist in different states of dormancy, with persisters and viable-but-nonculturable cells (VBNCs) constituting two modes thought to contribute to infections. Recently, Bollen and colleagues discovered that the state of protein aggregates inside cells impacts the depth of dormancy in individual bacteria, with solidification pushing them further into quiescence.

Original language	English (US)
Pages (from-to)	385-386
Number of pages	2
Journal	Trends in Microbiology
Volume	33
Issue number	4
DOIs	https://doi.org/10.1016/j.tim.2025.03.001
State	Published - Apr 2025

All Science Journal Classification (ASJC) codes

Microbiology
Microbiology (medical)
Virology
Infectious Diseases

Keywords

DnaK
VBNC
biomolecular condensate
persister
phase transition

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10.1016/j.tim.2025.03.001

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title = "Solidification of protein aggregates deepens bacterial dormancy",

abstract = "Bacteria can exist in different states of dormancy, with persisters and viable-but-nonculturable cells (VBNCs) constituting two modes thought to contribute to infections. Recently, Bollen and colleagues discovered that the state of protein aggregates inside cells impacts the depth of dormancy in individual bacteria, with solidification pushing them further into quiescence.",

keywords = "DnaK, VBNC, biomolecular condensate, persister, phase transition",

author = "Sniezek, {Katherine J.} and Nashaly Soto-Echevarria and Brynildsen, {Mark P.}",

note = "Publisher Copyright: {\textcopyright} 2025 Elsevier Ltd",

year = "2025",

month = apr,

doi = "10.1016/j.tim.2025.03.001",

language = "English (US)",

volume = "33",

pages = "385--386",

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T1 - Solidification of protein aggregates deepens bacterial dormancy

AU - Sniezek, Katherine J.

AU - Soto-Echevarria, Nashaly

AU - Brynildsen, Mark P.

PY - 2025/4

Y1 - 2025/4

N2 - Bacteria can exist in different states of dormancy, with persisters and viable-but-nonculturable cells (VBNCs) constituting two modes thought to contribute to infections. Recently, Bollen and colleagues discovered that the state of protein aggregates inside cells impacts the depth of dormancy in individual bacteria, with solidification pushing them further into quiescence.

AB - Bacteria can exist in different states of dormancy, with persisters and viable-but-nonculturable cells (VBNCs) constituting two modes thought to contribute to infections. Recently, Bollen and colleagues discovered that the state of protein aggregates inside cells impacts the depth of dormancy in individual bacteria, with solidification pushing them further into quiescence.

KW - DnaK

KW - VBNC

KW - biomolecular condensate

KW - persister

KW - phase transition

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U2 - 10.1016/j.tim.2025.03.001

DO - 10.1016/j.tim.2025.03.001

M3 - Short survey

C2 - 40113516

AN - SCOPUS:105001079443

SN - 0966-842X

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SP - 385

EP - 386

JO - Trends in Microbiology

JF - Trends in Microbiology

IS - 4

ER -

Solidification of protein aggregates deepens bacterial dormancy

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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