SNARE Protein Structure and Function

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234 Scopus citations


The SNARE superfamily has become, since its discovery approximately a decade ago, the most intensively studied element of the protein machinery involved in intracellular trafficking. Intracellular membrane fusion in eukaryotes requires SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) proteins that form complexes bridging the two membranes. Although common themes have emerged from structural and functional studies of SNAREs and other components of the eukaryotic membrane fusion machinery, there is still much to learn about how the assembly and activity of this machinery is choreographed in living cells.

Original languageEnglish (US)
Pages (from-to)493-517
Number of pages25
JournalAnnual review of cell and developmental biology
StatePublished - Dec 11 2003

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology


  • Intracellular trafficking
  • Membrane fusion
  • Neurotransmitter release
  • Rab protein
  • SM protein


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