Fluoroarene-Cr(CO)2L complexes with L = CO, PPh3, P(OPh)3, P(pyrrolyl)3, and P(pyrrolyl)2(NMeBn) have been evaluated for rates of nucleophilic substitution by amines and other nucleophiles. While there is a strong effect on relative rates depending on nucleophile type and the electronic effects of L, the P(pyrrolyl)3 and P(pyrrolyl)2-(NMeBn) complexes show general reactivity comparable to the parent complexes, with L = CO.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry
- Nucleophilic substitution