S(n)AR reactions with fluoroarene-Cr(CO)2L complexes, where L is a potential linker ligand for solid phase synthesis

Martin F. Semmelhack, Gerhard Hilt, Jeremy H. Colley

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Fluoroarene-Cr(CO)2L complexes with L = CO, PPh3, P(OPh)3, P(pyrrolyl)3, and P(pyrrolyl)2(NMeBn) have been evaluated for rates of nucleophilic substitution by amines and other nucleophiles. While there is a strong effect on relative rates depending on nucleophile type and the electronic effects of L, the P(pyrrolyl)3 and P(pyrrolyl)2-(NMeBn) complexes show general reactivity comparable to the parent complexes, with L = CO.

Original languageEnglish (US)
Pages (from-to)7683-7686
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number42
DOIs
StatePublished - Oct 15 1998

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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