TY - JOUR
T1 - Small animal models for human immunodeficiency virus (HIV), hepatitis b, and tuberculosis
T2 - Proceedings of an NIAID workshop
AU - Akkina, Ramesh
AU - Barber, Daniel L.
AU - Bility, Moses T.
AU - Bissig, Karl Dimiter
AU - Burwitz, Benjamin J.
AU - Eichelberg, Katrin
AU - Endsley, Janice J.
AU - Garcia, J. Victor
AU - Hafner, Richard
AU - Karakousis, Petros C.
AU - Korba, Brent E.
AU - Koshy, Rajen
AU - Lambros, Chris
AU - Menne, Stephan
AU - Nuermberger, Eric L.
AU - Ploss, Alexander
AU - Podell, Brendan K.
AU - Poluektova, Larisa Y.
AU - Sanders-Beer, Brigitte E.
AU - Subbian, Selvakumar
AU - Wahl, Angela
N1 - Publisher Copyright:
© 2020 Bentham Science Publishers.
PY - 2020
Y1 - 2020
N2 - The main advantage of animal models of infectious diseases over in vitro studies is the gain in the understanding of the complex dynamics between the immune system and the pathogen. While small animal models have practical advantages over large animal models, it is crucial to be aware of their limitations. Although the small animal model at least needs to be susceptible to the pathogen under study to obtain meaningful data, key elements of pathogenesis should also be reflected when compared to humans. Well-designed small animal models for HIV, hepatitis viruses and tuberculosis require, additionally, a thorough understanding of the similarities and differences in the immune responses between humans and small animals and should incorporate that knowledge into the goals of the study. To discuss these considerations, the NIAID hosted a workshop on ‘Small Animal Models for HIV, Hepatitis B, and Tuberculosis’ on May 30, 2019. Highlights of the workshop are outlined below.
AB - The main advantage of animal models of infectious diseases over in vitro studies is the gain in the understanding of the complex dynamics between the immune system and the pathogen. While small animal models have practical advantages over large animal models, it is crucial to be aware of their limitations. Although the small animal model at least needs to be susceptible to the pathogen under study to obtain meaningful data, key elements of pathogenesis should also be reflected when compared to humans. Well-designed small animal models for HIV, hepatitis viruses and tuberculosis require, additionally, a thorough understanding of the similarities and differences in the immune responses between humans and small animals and should incorporate that knowledge into the goals of the study. To discuss these considerations, the NIAID hosted a workshop on ‘Small Animal Models for HIV, Hepatitis B, and Tuberculosis’ on May 30, 2019. Highlights of the workshop are outlined below.
KW - AIDS
KW - Animal models
KW - Co-infections
KW - HBV
KW - HIV
KW - Tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=85081143670&partnerID=8YFLogxK
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U2 - 10.2174/1570162X18666191223114019
DO - 10.2174/1570162X18666191223114019
M3 - Article
C2 - 31870268
AN - SCOPUS:85081143670
SN - 1570-162X
VL - 18
SP - 19
EP - 28
JO - Current HIV Research
JF - Current HIV Research
IS - 1
ER -