slam encodes a developmental regulator of polarized membrane growth during cleavage of the Drosphila embryo

Thomas Lecuit, Reba Samanta, Eric Wieschaus

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

Cellularization of the Drosophila embryo is a specialized form of cytokinesis that couples membrane growth with the formation of a polarized epithelium. We have identified a gene essential for polarized growth of the plasma membrane during cellularization. In slam mutant embryos, the furrow canal is disorganized, and polarized insertion of transmembrane proteins is disrupted. slam shows a striking developmental induction during the slow phase of cellularization, and Slam protein localizes to the furrow canal and the basal junction. Slam colocalizes with the junctional proteins Arm/β-catenin, the PDZ domain-containing protein Dlt, and Myosin and is also required for their proper membrane localization. Our results suggest that developmental induction of Slam organizes the polarized growth of membranes via the recruitment of membrane-targeting proteins at adherens junctions.

Original languageEnglish (US)
Pages (from-to)425-436
Number of pages12
JournalDevelopmental cell
Volume2
Issue number4
DOIs
StatePublished - Jan 1 2002

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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