TY - JOUR
T1 - Siv-induced instability of the chimpanzee gut microbiome
AU - Moeller, Andrew H.
AU - Shilts, Meghan
AU - Li, Yingying
AU - Rudicell, Rebecca S.
AU - Lonsdorf, Elizabeth V.
AU - Pusey, Anne E.
AU - Wilson, Michael L.
AU - Hahn, Beatrice H.
AU - Ochman, Howard
PY - 2013/9/11
Y1 - 2013/9/11
N2 - Simian immunodeficiency virus of chimpanzees (SIVcpz) is the ancestor of human immunodeficiency virus type 1 (HIV-1), the etiologic agent of acquired immunodeficiency syndrome (AIDS) in humans. Like HIV-1-infected humans, SIVcpz-infected chimpanzees can develop AIDS-like symptoms. Because SIVcpz/HIV-1 may disrupt regulation of the gut microbiome and because it has not been possible to sample individual humans pre- and postinfection, we investigated the influence of infection on gut communities through long-term monitoring of chimpanzees from Gombe National Park, Tanzania. SIVcpz infection accelerated the rate of change in gut microbiota composition within individuals for periods of years after the initial infection and led to gut communities marked by high frequencies of pathogen-containing bacterial genera absent from SIVcpz-negative individuals. Our results indicate that immune function maintains temporally stable gut communities that are lost when individuals become infected with SIVcpz.
AB - Simian immunodeficiency virus of chimpanzees (SIVcpz) is the ancestor of human immunodeficiency virus type 1 (HIV-1), the etiologic agent of acquired immunodeficiency syndrome (AIDS) in humans. Like HIV-1-infected humans, SIVcpz-infected chimpanzees can develop AIDS-like symptoms. Because SIVcpz/HIV-1 may disrupt regulation of the gut microbiome and because it has not been possible to sample individual humans pre- and postinfection, we investigated the influence of infection on gut communities through long-term monitoring of chimpanzees from Gombe National Park, Tanzania. SIVcpz infection accelerated the rate of change in gut microbiota composition within individuals for periods of years after the initial infection and led to gut communities marked by high frequencies of pathogen-containing bacterial genera absent from SIVcpz-negative individuals. Our results indicate that immune function maintains temporally stable gut communities that are lost when individuals become infected with SIVcpz.
UR - http://www.scopus.com/inward/record.url?scp=84883860231&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84883860231&partnerID=8YFLogxK
U2 - 10.1016/j.chom.2013.08.005
DO - 10.1016/j.chom.2013.08.005
M3 - Article
C2 - 24034619
AN - SCOPUS:84883860231
SN - 1931-3128
VL - 14
SP - 340
EP - 345
JO - Cell Host and Microbe
JF - Cell Host and Microbe
IS - 3
ER -