@article{446680aabbc4487a9da2797ed3549e24,
title = "Site-selective 18F fluorination of unactivated C-H bonds mediated by a manganese porphyrin",
abstract = "The first direct C-H 18F fluorination reaction of unactivated aliphatic sites using no-carrier-Added [18F]fluoride is reported. Under the influence of a manganese porphyrin/iodosylbenzene system, a variety of unactivated aliphatic C-H bonds can be selectively converted to C-18F bonds. The mild conditions, broad substrate scope and generally inaccessible regiochemistry make this radio-fluorination a powerful alternate to established nucleophilic substitution for the preparation of 18F labeled radio tracers.",
author = "Wei Liu and Xiongyi Huang and Placzek, {Michael S.} and Krska, {Shane W.} and Paul McQuade and Hooker, {Jacob M.} and Groves, {John Taylor}",
note = "Funding Information: This research was supported by the US National Science Foundation award CHE-1464578 (J. T. G.) and in part by the Center for Catalytic Hydrocarbon Functionalization, an Energy Frontier Research Center, U.S. Department of Energy, Office of Science, Basic Energy Sciences, under Award No. DE SC0001298 (J. T. G.). Portions of this research were carried out by W. L. and X.H. at the Merck Research Laboratories, Rahway, NJ and the Martinos Center for Biomedical Imaging using resources provided by the Center for Functional Neuroimaging Technologies, P41EB015896, and shared instrumentation grants S10RR017208 and S10RR023452. We also thank Dr Hong Ren for assistance on the radiochemistry. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2018.",
year = "2018",
doi = "10.1039/c7sc04545j",
language = "English (US)",
volume = "9",
pages = "1168--1172",
journal = "Chemical Science",
issn = "2041-6520",
publisher = "Royal Society of Chemistry",
number = "5",
}