Single-trial spike trains in parietal cortex reveal discrete steps during decision-making

Kenneth W. Latimer, Jacob L. Yates, Miriam L.R. Meister, Alexander C. Huk, Jonathan W. Pillow

Research output: Contribution to journalArticle

116 Scopus citations

Abstract

Neurons in the macaque lateral intraparietal (LIP) area exhibit firing rates that appear to ramp upward or downward during decision-making. These ramps are commonly assumed to reflect the gradual accumulation of evidence toward a decision threshold. However, the ramping in trial-averaged responses could instead arise from instantaneous jumps at different times on different trials. We examined single-trial responses in LIP using statistical methods for fitting and comparing latent dynamical spike-train models. We compared models with latent spike rates governed by either continuous diffusion-to-bound dynamics or discrete "stepping" dynamics. Roughly three-quarters of the choice-selective neurons we recorded were better described by the stepping model. Moreover, the inferred steps carried more information about the animal's choice than spike counts.

Original languageEnglish (US)
Pages (from-to)184-187
Number of pages4
JournalScience
Volume349
Issue number6244
DOIs
StatePublished - Jul 10 2015

All Science Journal Classification (ASJC) codes

  • General

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