TY - JOUR
T1 - Single-Particle Cryo-Electron Microscopy
T2 - Mathematical Theory, Computational Challenges, and Opportunities
AU - Bendory, Tamir
AU - Bartesaghi, Alberto
AU - Singer, Amit
N1 - Funding Information:
We thank the anonymous reviewers and Jong Chul Ye for their valuable comments and suggestions. Amit Singer was supported in part by award R01GM090200 from the National Institute of General Medical Sciences, FA9550-17-1-0291 from the Air Force Office of Scientific Research, Simons Foundation Math+X Investigator Award, the Moore Foundation Data-Driven Discovery Investigator Award, and National Science Foundation BIGDATA Award IIS-1837992.
Publisher Copyright:
© 2020 IEEE.
PY - 2020/3
Y1 - 2020/3
N2 - In recent years, an abundance of new molecular structures have been elucidated using cryo-electron microscopy (cryo-EM), largely due to advances in hardware technology and data processing techniques. Owing to these exciting new developments, cryo-EM was selected by Nature Methods as the "Method of the Year 2015," and the Nobel Prize in Chemistry 2017 was awarded to three pioneers in the cryo-EM field: Jacques Dubochet, Joachim Frank, and Richard Henderson "for developing cryoelectron microscopy for the high-resolution structure determination of biomolecules in solution" [93].
AB - In recent years, an abundance of new molecular structures have been elucidated using cryo-electron microscopy (cryo-EM), largely due to advances in hardware technology and data processing techniques. Owing to these exciting new developments, cryo-EM was selected by Nature Methods as the "Method of the Year 2015," and the Nobel Prize in Chemistry 2017 was awarded to three pioneers in the cryo-EM field: Jacques Dubochet, Joachim Frank, and Richard Henderson "for developing cryoelectron microscopy for the high-resolution structure determination of biomolecules in solution" [93].
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U2 - 10.1109/MSP.2019.2957822
DO - 10.1109/MSP.2019.2957822
M3 - Article
AN - SCOPUS:85080959338
SN - 1053-5888
VL - 37
SP - 58
EP - 76
JO - IEEE Signal Processing Magazine
JF - IEEE Signal Processing Magazine
IS - 2
M1 - 9016106
ER -