Single-Particle Cryo-Electron Microscopy: Mathematical Theory, Computational Challenges, and Opportunities

Tamir Bendory, Alberto Bartesaghi, Amit Singer

Research output: Contribution to journalArticlepeer-review

86 Scopus citations


In recent years, an abundance of new molecular structures have been elucidated using cryo-electron microscopy (cryo-EM), largely due to advances in hardware technology and data processing techniques. Owing to these exciting new developments, cryo-EM was selected by Nature Methods as the "Method of the Year 2015," and the Nobel Prize in Chemistry 2017 was awarded to three pioneers in the cryo-EM field: Jacques Dubochet, Joachim Frank, and Richard Henderson "for developing cryoelectron microscopy for the high-resolution structure determination of biomolecules in solution" [93].

Original languageEnglish (US)
Article number9016106
Pages (from-to)58-76
Number of pages19
JournalIEEE Signal Processing Magazine
Issue number2
StatePublished - Mar 2020

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Electrical and Electronic Engineering
  • Applied Mathematics


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