Simplified dynamics in a model of noradrenergic modulation of cognitive performance

Mark S. Gilzenrat; Benjamin D. Holmes; Janusz Rajkowski; Gary Aston-Jones; Jonathan D. Cohen

doi:10.1016/S0893-6080(02)00055-2

Simplified dynamics in a model of noradrenergic modulation of cognitive performance

Mark S. Gilzenrat, Benjamin D. Holmes, Janusz Rajkowski, Gary Aston-Jones, Jonathan D. Cohen

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24 Scopus citations

Abstract

Neurophysiological work in monkeys has shown that changes in tonic and stimulus-induced activity in the noradrenergic brainstem nucleus locus coeruleus (LC) are tightly correlated with fluctuations in behavioral performance in a visual discrimination task. Simulation work suggests transitions between observed modes of LC activity may be mediated by changes in the level of coherent firing among individual LC neurons. We have simplified this simulation by abstracting the LC to a simple, excitable system in two variables modeled after the FitzHugh-Nagumo relaxation oscillator. This abstracted LC simulates population-level dynamics of the nucleus relevant to its influence on behavior. Coherence within the nucleus was simulated as a single parameter which amplified external input to the abstracted LC while attenuating tonic, uncorrelated activity. Simulated results captured LC dynamics and their relationship with behavior observed in monkeys. Behavior was further simulated over a range of potential LC states not, as yet, directly observed. These results suggest a reverse sigmoidal relationship between false alarm rate and coherence, and a more complex, non-monotonic relationship between response time and coherence.

Original language	English (US)
Pages (from-to)	647-663
Number of pages	17
Journal	Neural Networks
Volume	15
Issue number	4-6
DOIs	https://doi.org/10.1016/S0893-6080(02)00055-2
State	Published - Jun 2002

All Science Journal Classification (ASJC) codes

Artificial Intelligence
Cognitive Neuroscience

Keywords

Attention
Connectionist model
Electrotonic coupling
FitzHugh-Nagumo
Locus coeruleus
Norepinephrine

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10.1016/S0893-6080(02)00055-2

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title = "Simplified dynamics in a model of noradrenergic modulation of cognitive performance",

abstract = "Neurophysiological work in monkeys has shown that changes in tonic and stimulus-induced activity in the noradrenergic brainstem nucleus locus coeruleus (LC) are tightly correlated with fluctuations in behavioral performance in a visual discrimination task. Simulation work suggests transitions between observed modes of LC activity may be mediated by changes in the level of coherent firing among individual LC neurons. We have simplified this simulation by abstracting the LC to a simple, excitable system in two variables modeled after the FitzHugh-Nagumo relaxation oscillator. This abstracted LC simulates population-level dynamics of the nucleus relevant to its influence on behavior. Coherence within the nucleus was simulated as a single parameter which amplified external input to the abstracted LC while attenuating tonic, uncorrelated activity. Simulated results captured LC dynamics and their relationship with behavior observed in monkeys. Behavior was further simulated over a range of potential LC states not, as yet, directly observed. These results suggest a reverse sigmoidal relationship between false alarm rate and coherence, and a more complex, non-monotonic relationship between response time and coherence.",

keywords = "Attention, Connectionist model, Electrotonic coupling, FitzHugh-Nagumo, Locus coeruleus, Norepinephrine",

author = "Gilzenrat, {Mark S.} and Holmes, {Benjamin D.} and Janusz Rajkowski and Gary Aston-Jones and Cohen, {Jonathan D.}",

note = "Funding Information: The authors would like to gratefully acknowledge the comments, criticisms, and expert contributions of Philip Holmes and Eric Brown. This work was supported by National Institutes of Health grants R01MH59978 and P50MH62196, and a National Science Foundation Graduate Research Fellowship to M.S.G. A portion of this work was presented in a poster session at the 2001 annual meeting of the Society For Neuroscience in San Diego, CA, USA. ",

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AU - Gilzenrat, Mark S.

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AU - Rajkowski, Janusz

AU - Aston-Jones, Gary

AU - Cohen, Jonathan D.

N1 - Funding Information: The authors would like to gratefully acknowledge the comments, criticisms, and expert contributions of Philip Holmes and Eric Brown. This work was supported by National Institutes of Health grants R01MH59978 and P50MH62196, and a National Science Foundation Graduate Research Fellowship to M.S.G. A portion of this work was presented in a poster session at the 2001 annual meeting of the Society For Neuroscience in San Diego, CA, USA.

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N2 - Neurophysiological work in monkeys has shown that changes in tonic and stimulus-induced activity in the noradrenergic brainstem nucleus locus coeruleus (LC) are tightly correlated with fluctuations in behavioral performance in a visual discrimination task. Simulation work suggests transitions between observed modes of LC activity may be mediated by changes in the level of coherent firing among individual LC neurons. We have simplified this simulation by abstracting the LC to a simple, excitable system in two variables modeled after the FitzHugh-Nagumo relaxation oscillator. This abstracted LC simulates population-level dynamics of the nucleus relevant to its influence on behavior. Coherence within the nucleus was simulated as a single parameter which amplified external input to the abstracted LC while attenuating tonic, uncorrelated activity. Simulated results captured LC dynamics and their relationship with behavior observed in monkeys. Behavior was further simulated over a range of potential LC states not, as yet, directly observed. These results suggest a reverse sigmoidal relationship between false alarm rate and coherence, and a more complex, non-monotonic relationship between response time and coherence.

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KW - Norepinephrine

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Simplified dynamics in a model of noradrenergic modulation of cognitive performance

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