Simple and efficient resolution of l,1′-bi-2-naphthol

Dongwei Cai, David L. Hughes, Thomas R. Verhoeven, Paul J. Reider

Research output: Contribution to journalArticlepeer-review

168 Scopus citations


Acetonitrile is a crucial solvent for a simple and efficient resolution of l,l′-bi-2-naphthol using N-benzylcincbonidium chloride. Both enantiomers can be easily obtained with ≥95% yield and ≥99% ee.

Original languageEnglish (US)
Pages (from-to)7991-7994
Number of pages4
JournalTetrahedron Letters
Issue number44
StatePublished - Oct 30 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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