@article{4408fd0a39174357a39bee069388f70d,
title = "Sex differences in oncogenic mutational processes",
abstract = "Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes. These results underline the pervasiveness of molecular sex differences and strengthen the call for increased consideration of sex in molecular cancer research.",
author = "{PCAWG Tumour Subtypes and Clinical Translation} and {PCAWG Consortium} and Li, {Constance H.} and Prokopec, {Stephenie D.} and Sun, {Ren X.} and Fouad Yousif and Nathaniel Schmitz and Fatima Al-Shahrour and Gurnit Atwal and Bailey, {Peter J.} and Biankin, {Andrew V.} and Boutros, {Paul C.} and Campbell, {Peter J.} and Chang, {David K.} and Cooke, {Susanna L.} and Vikram Deshpande and Faltas, {Bishoy M.} and Faquin, {William C.} and Levi Garraway and Gad Getz and Grimmond, {Sean M.} and Syed Haider and Hoadley, {Katherine A.} and Wei Jiao and Kaiser, {Vera B.} and Rosa Karli{\'c} and Mamoru Kato and Kirsten K{\"u}bler and Lazar, {Alexander J.} and Li, {Constance H.} and Louis, {David N.} and Adam Margolin and Sancha Martin and Nahal-Bose, {Hardeep K.} and Nielsen, {G. Petur} and Serena Nik-Zainal and Larsson Omberg and Christine P{\textquoteright}ng and Perry, {Marc D.} and Paz Polak and Esther Rheinbay and Rubin, {Mark A.} and Semple, {Colin A.} and Sgroi, {Dennis C.} and Tatsuhiro Shibata and Reiner Siebert and Jaclyn Smith and Stein, {Lincoln D.} and Stobbe, {Miranda D.} and Sun, {Ren X.} and Kevin Thai and Raphael, {Benjamin J.}",
note = "Publisher Copyright: {\textcopyright} 2020, The Author(s).",
year = "2020",
month = dec,
day = "1",
doi = "10.1038/s41467-020-17359-2",
language = "English (US)",
volume = "11",
journal = "Nature communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}