Serotonin turnover in raphe neurons transplanted into rat hippocampus

Sidney Auerbach; Feng Zhou; Barry L. Jacobs; Efrain Azmitia

doi:10.1016/0304-3940(85)90416-1

Serotonin turnover in raphe neurons transplanted into rat hippocampus

Sidney Auerbach, Feng Zhou, Barry L. Jacobs, Efrain Azmitia

Psychology

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Injections of the neurotoxin, 5,7-dihydroxytryptamine, into rostral raphe nuclei in rats reduced serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in hippocampus to 35-;50% of normal levels but only reduced 5-HT synthesis and catabolism by 20-35%. The small reduction in 5-HT metabolism as compared to depletion of 5-HT suggests that 5-HT turnover was increased in nerve terminals that survived the neurotoxin lesion. Transplantation of rat fetal raphe cells into the 5-HT-denervated hippocampus restored 5-HT and 5-HIAA levels and 5-HT synthesis to 125-150% of normal. This demonstrates that transplantation of fetal raphe tissue can restore metabolism to normal levels in the 5-HT-denervated hippocampus.

Original language	English (US)
Pages (from-to)	147-152
Number of pages	6
Journal	Neuroscience Letters
Volume	61
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(85)90416-1
State	Published - Oct 24 1985

All Science Journal Classification (ASJC) codes

General Neuroscience

Keywords

hippocampus
rat
serotonin
serotonin neuron
transplantation
turnover

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10.1016/0304-3940(85)90416-1

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title = "Serotonin turnover in raphe neurons transplanted into rat hippocampus",

abstract = "Injections of the neurotoxin, 5,7-dihydroxytryptamine, into rostral raphe nuclei in rats reduced serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in hippocampus to 35-;50\% of normal levels but only reduced 5-HT synthesis and catabolism by 20-35\%. The small reduction in 5-HT metabolism as compared to depletion of 5-HT suggests that 5-HT turnover was increased in nerve terminals that survived the neurotoxin lesion. Transplantation of rat fetal raphe cells into the 5-HT-denervated hippocampus restored 5-HT and 5-HIAA levels and 5-HT synthesis to 125-150\% of normal. This demonstrates that transplantation of fetal raphe tissue can restore metabolism to normal levels in the 5-HT-denervated hippocampus.",

keywords = "hippocampus, rat, serotonin, serotonin neuron, transplantation, turnover",

author = "Sidney Auerbach and Feng Zhou and Jacobs, \{Barry L.\} and Efrain Azmitia",

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T1 - Serotonin turnover in raphe neurons transplanted into rat hippocampus

AU - Auerbach, Sidney

AU - Zhou, Feng

AU - Jacobs, Barry L.

AU - Azmitia, Efrain

PY - 1985/10/24

Y1 - 1985/10/24

N2 - Injections of the neurotoxin, 5,7-dihydroxytryptamine, into rostral raphe nuclei in rats reduced serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in hippocampus to 35-;50% of normal levels but only reduced 5-HT synthesis and catabolism by 20-35%. The small reduction in 5-HT metabolism as compared to depletion of 5-HT suggests that 5-HT turnover was increased in nerve terminals that survived the neurotoxin lesion. Transplantation of rat fetal raphe cells into the 5-HT-denervated hippocampus restored 5-HT and 5-HIAA levels and 5-HT synthesis to 125-150% of normal. This demonstrates that transplantation of fetal raphe tissue can restore metabolism to normal levels in the 5-HT-denervated hippocampus.

AB - Injections of the neurotoxin, 5,7-dihydroxytryptamine, into rostral raphe nuclei in rats reduced serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in hippocampus to 35-;50% of normal levels but only reduced 5-HT synthesis and catabolism by 20-35%. The small reduction in 5-HT metabolism as compared to depletion of 5-HT suggests that 5-HT turnover was increased in nerve terminals that survived the neurotoxin lesion. Transplantation of rat fetal raphe cells into the 5-HT-denervated hippocampus restored 5-HT and 5-HIAA levels and 5-HT synthesis to 125-150% of normal. This demonstrates that transplantation of fetal raphe tissue can restore metabolism to normal levels in the 5-HT-denervated hippocampus.

KW - hippocampus

KW - rat

KW - serotonin

KW - serotonin neuron

KW - transplantation

KW - turnover

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ER -

Serotonin turnover in raphe neurons transplanted into rat hippocampus

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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