Abstract
Injections of the neurotoxin, 5,7-dihydroxytryptamine, into rostral raphe nuclei in rats reduced serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in hippocampus to 35-;50% of normal levels but only reduced 5-HT synthesis and catabolism by 20-35%. The small reduction in 5-HT metabolism as compared to depletion of 5-HT suggests that 5-HT turnover was increased in nerve terminals that survived the neurotoxin lesion. Transplantation of rat fetal raphe cells into the 5-HT-denervated hippocampus restored 5-HT and 5-HIAA levels and 5-HT synthesis to 125-150% of normal. This demonstrates that transplantation of fetal raphe tissue can restore metabolism to normal levels in the 5-HT-denervated hippocampus.
Original language | English (US) |
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Pages (from-to) | 147-152 |
Number of pages | 6 |
Journal | Neuroscience Letters |
Volume | 61 |
Issue number | 1-2 |
DOIs | |
State | Published - Oct 24 1985 |
All Science Journal Classification (ASJC) codes
- General Neuroscience
Keywords
- hippocampus
- rat
- serotonin
- serotonin neuron
- transplantation
- turnover