Serotonin and hippocampal neurogenesis

Elizabeth Gould

doi:10.1016/S0893-133X(99)00045-7

Serotonin and hippocampal neurogenesis

Elizabeth Gould

Research output: Contribution to journal › Article › peer-review

301 Scopus citations

Abstract

The dentate gyrus continues to produce new granule neurons well into adulthood. This has been demonstrated for many mammalian species, from rodents to primates. The proliferation of granule cell precursors can be suppressed by stressful experiences, presumably via adrenal steroids. Recent evidence suggests that serotonin can enhance the production of new neurons via activation of the 5HT1Areceptor. These results present the possibility that the inhibitory effects of stress on granule cell production may be prevented by 5HT1 A receptor agonists.

Original language	English (US)
Pages (from-to)	46S-51S
Journal	Neuropsychopharmacology
Volume	21
DOIs	https://doi.org/10.1016/S0893-133X(99)00045-7
State	Published - Aug 1999

All Science Journal Classification (ASJC) codes

Psychiatry and Mental health
Pharmacology

Keywords

5HT1A receptor
Dentate gyrus
Granule cell
Hippocampus
Neurogenesis
Stress

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10.1016/S0893-133X(99)00045-7

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AB - The dentate gyrus continues to produce new granule neurons well into adulthood. This has been demonstrated for many mammalian species, from rodents to primates. The proliferation of granule cell precursors can be suppressed by stressful experiences, presumably via adrenal steroids. Recent evidence suggests that serotonin can enhance the production of new neurons via activation of the 5HT1Areceptor. These results present the possibility that the inhibitory effects of stress on granule cell production may be prevented by 5HT1 A receptor agonists.

KW - 5HT1A receptor

KW - Dentate gyrus

KW - Granule cell

KW - Hippocampus

KW - Neurogenesis

KW - Stress

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ER -

Serotonin and hippocampal neurogenesis

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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