Abstract
(formula presented) Sequential reactions of nitromethane via conjugate addition - elimination to B-trifloxy acrylates followed by Pd-catalyzed substitution of the resulting allyl nitro compounds with nucleophiles afforded homologation products at the β-position. 2-Naphthosultammethyl carbapenem, pan anti-MRS carbapenem intermediate, was prepared in one pot from the corresponding 2-trifloxy compound. The scope and limitation of the one-pot method were investigated using several cyclic unsaturated esters and nucleophiles.
Original language | English (US) |
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Pages (from-to) | 1783-1785 |
Number of pages | 3 |
Journal | Organic Letters |
Volume | 1 |
Issue number | 11 |
DOIs | |
State | Published - Dec 2 1999 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry