Sequence-independent autoregulation of the adenovirus type 5 E1A transcription unit

P. Hearing, T. Shenk

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


The adenovirus E1A gene is known to be autoregulated at the level of transcription. Autoregulation was found to be mediated by products of the E1A 13S mRNA, which induced a fivefold increase in E1A transcription rate. Deletion analysis suggested that the autoregulation did not require any specific sequence in the E1A transcriptional control region. This conclusion was reinforced by the demonstration that a cellular α-globin gene substituted for the E1A gene on the adenovirus chromosome was also positively regulated by E1A gene products.

Original languageEnglish (US)
Pages (from-to)3214-3221
Number of pages8
JournalMolecular and cellular biology
Issue number11
StatePublished - 1985

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology


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