Sequence analysis of mutations that prevent export of λ receptor, an Escherichia coli outer membrane protein

Scott D. Emr; Joe Hedgpeth; Jean Marie Clément; Thomas J. Silhavy; Maurice Hofnung

doi:10.1038/285082a0

Sequence analysis of mutations that prevent export of λ receptor, an Escherichia coli outer membrane protein

Scott D. Emr, Joe Hedgpeth, Jean Marie Clément, Thomas J. Silhavy, Maurice Hofnung

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112 Scopus citations

Abstract

The ammo-terminal signal sequence is required for initiation of transmembrane protein transfer of the Escherichia coli λ receptor protein. Mutations leading to insertion of charged amino acids into or deletion of amino acids from the hydrophobic segment of this sequence prevent export of this outer membrane protein.

Original language	English (US)
Pages (from-to)	82-85
Number of pages	4
Journal	Nature
Volume	285
Issue number	5760
DOIs	https://doi.org/10.1038/285082a0
State	Published - 1980
Externally published	Yes

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@article{f327ffd31b60402ca8dadc541e0bfa9b,

title = "Sequence analysis of mutations that prevent export of λ receptor, an Escherichia coli outer membrane protein",

abstract = "The ammo-terminal signal sequence is required for initiation of transmembrane protein transfer of the Escherichia coli λ receptor protein. Mutations leading to insertion of charged amino acids into or deletion of amino acids from the hydrophobic segment of this sequence prevent export of this outer membrane protein.",

author = "Emr, \{Scott D.\} and Joe Hedgpeth and Cl{\'e}ment, \{Jean Marie\} and Silhavy, \{Thomas J.\} and Maurice Hofnung",

year = "1980",

doi = "10.1038/285082a0",

language = "English (US)",

volume = "285",

pages = "82--85",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Research",

number = "5760",

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T1 - Sequence analysis of mutations that prevent export of λ receptor, an Escherichia coli outer membrane protein

AU - Emr, Scott D.

AU - Hedgpeth, Joe

AU - Clément, Jean Marie

AU - Silhavy, Thomas J.

AU - Hofnung, Maurice

PY - 1980

Y1 - 1980

N2 - The ammo-terminal signal sequence is required for initiation of transmembrane protein transfer of the Escherichia coli λ receptor protein. Mutations leading to insertion of charged amino acids into or deletion of amino acids from the hydrophobic segment of this sequence prevent export of this outer membrane protein.

AB - The ammo-terminal signal sequence is required for initiation of transmembrane protein transfer of the Escherichia coli λ receptor protein. Mutations leading to insertion of charged amino acids into or deletion of amino acids from the hydrophobic segment of this sequence prevent export of this outer membrane protein.

UR - https://www.scopus.com/pages/publications/0018939725

UR - https://www.scopus.com/inward/citedby.url?scp=0018939725&partnerID=8YFLogxK

U2 - 10.1038/285082a0

DO - 10.1038/285082a0

M3 - Article

C2 - 6445509

AN - SCOPUS:0018939725

SN - 0028-0836

VL - 285

SP - 82

EP - 85

JO - Nature

JF - Nature

IS - 5760

ER -

Sequence analysis of mutations that prevent export of λ receptor, an Escherichia coli outer membrane protein

Abstract

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