Qtip is a 79 amino acid antirepressor that connects phage quorum sensing to host-cell lysis. Silpe and Bridges et al. demonstrate that Qtip binds, inactivates, and sequesters the phage cI repressor at the cell pole. Qtip mutagenesis reveals discrete sites required for repressor recognition and polar localization, showing that the two functions are separable.
All Science Journal Classification (ASJC) codes
- cI repressor
- quorum sensing