Separating Functions of the Phage-Encoded Quorum-Sensing-Activated Antirepressor Qtip

Justin E. Silpe; Andrew A. Bridges; Xiuliang Huang; Daniela R. Coronado; Olivia P. Duddy; Bonnie L. Bassler

doi:10.1016/j.chom.2020.01.024

Separating Functions of the Phage-Encoded Quorum-Sensing-Activated Antirepressor Qtip

Justin E. Silpe, Andrew A. Bridges, Xiuliang Huang, Daniela R. Coronado, Olivia P. Duddy, Bonnie L. Bassler

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Qtip is a 79 amino acid antirepressor that connects phage quorum sensing to host-cell lysis. Silpe and Bridges et al. demonstrate that Qtip binds, inactivates, and sequesters the phage cI repressor at the cell pole. Qtip mutagenesis reveals discrete sites required for repressor recognition and polar localization, showing that the two functions are separable.

Original language	English (US)
Pages (from-to)	629-641.e4
Journal	Cell Host and Microbe
Volume	27
Issue number	4
DOIs	https://doi.org/10.1016/j.chom.2020.01.024
State	Published - Apr 8 2020

All Science Journal Classification (ASJC) codes

Parasitology
Microbiology
Virology

Keywords

Qtip
antirepressor
cI repressor
lysis-lysogeny
phage
quorum sensing

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10.1016/j.chom.2020.01.024

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title = "Separating Functions of the Phage-Encoded Quorum-Sensing-Activated Antirepressor Qtip",

abstract = "Qtip is a 79 amino acid antirepressor that connects phage quorum sensing to host-cell lysis. Silpe and Bridges et al. demonstrate that Qtip binds, inactivates, and sequesters the phage cI repressor at the cell pole. Qtip mutagenesis reveals discrete sites required for repressor recognition and polar localization, showing that the two functions are separable.",

keywords = "Qtip, antirepressor, cI repressor, lysis-lysogeny, phage, quorum sensing",

author = "Silpe, {Justin E.} and Bridges, {Andrew A.} and Xiuliang Huang and Coronado, {Daniela R.} and Duddy, {Olivia P.} and Bassler, {Bonnie L.}",

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AU - Silpe, Justin E.

AU - Bridges, Andrew A.

AU - Huang, Xiuliang

AU - Coronado, Daniela R.

AU - Duddy, Olivia P.

AU - Bassler, Bonnie L.

PY - 2020/4/8

Y1 - 2020/4/8

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AB - Qtip is a 79 amino acid antirepressor that connects phage quorum sensing to host-cell lysis. Silpe and Bridges et al. demonstrate that Qtip binds, inactivates, and sequesters the phage cI repressor at the cell pole. Qtip mutagenesis reveals discrete sites required for repressor recognition and polar localization, showing that the two functions are separable.

KW - Qtip

KW - antirepressor

KW - cI repressor

KW - lysis-lysogeny

KW - phage

KW - quorum sensing

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Separating Functions of the Phage-Encoded Quorum-Sensing-Activated Antirepressor Qtip

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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