Separating Functions of the Phage-Encoded Quorum-Sensing-Activated Antirepressor Qtip

Justin E. Silpe, Andrew A. Bridges, Xiuliang Huang, Daniela R. Coronado, Olivia P. Duddy, Bonnie L. Bassler

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Qtip is a 79 amino acid antirepressor that connects phage quorum sensing to host-cell lysis. Silpe and Bridges et al. demonstrate that Qtip binds, inactivates, and sequesters the phage cI repressor at the cell pole. Qtip mutagenesis reveals discrete sites required for repressor recognition and polar localization, showing that the two functions are separable.

Original languageEnglish (US)
Pages (from-to)629-641.e4
JournalCell Host and Microbe
Volume27
Issue number4
DOIs
StatePublished - Apr 8 2020

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Virology

Keywords

  • antirepressor
  • cI repressor
  • lysis-lysogeny
  • phage
  • Qtip
  • quorum sensing

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