Sensory transduction in bacterial chemotaxis involves phosphotransfer between CHE proteins

David Wylie; Ann Stock; Cing Yuen Wong; Jeff Stock

doi:10.1016/S0006-291X(88)80365-6

Sensory transduction in bacterial chemotaxis involves phosphotransfer between CHE proteins

David Wylie
, Ann Stock
, Cing Yuen Wong
, Jeff Stock

Research output: Contribution to journal › Article › peer-review

136 Scopus citations

Abstract

The CheA protein of the Salmonella typhimurium chemotaxis system is phosphorylated by ATP. Phospho-CheA transfers its phosphoryl group to a second chemotaxis protein, CheY. Unlike phospho-CheA, phospho-CheY is relatively unstable, rapidly decaying to phosphate and CheY. We propose that phosphorylation of CheY may play a role in its function as a tumble regulator to control motor behavior in response to attractant and repellent stimuli.

Original language	English (US)
Pages (from-to)	891-896
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	151
Issue number	2
DOIs	https://doi.org/10.1016/S0006-291X(88)80365-6
State	Published - Mar 15 1988

All Science Journal Classification (ASJC) codes

Molecular Biology
Biophysics
Biochemistry
Cell Biology

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title = "Sensory transduction in bacterial chemotaxis involves phosphotransfer between CHE proteins",

abstract = "The CheA protein of the Salmonella typhimurium chemotaxis system is phosphorylated by ATP. Phospho-CheA transfers its phosphoryl group to a second chemotaxis protein, CheY. Unlike phospho-CheA, phospho-CheY is relatively unstable, rapidly decaying to phosphate and CheY. We propose that phosphorylation of CheY may play a role in its function as a tumble regulator to control motor behavior in response to attractant and repellent stimuli.",

author = "David Wylie and Ann Stock and Wong, \{Cing Yuen\} and Jeff Stock",

note = "Funding Information: We wish to thank Saul Roseman for his support and advice. We also thank Alex Ninfa and Boris Magasanik for information concerning the Ntr system. Finally we extend thanks to Katrina Forest, Tom Chen, Linda Han, and Andrei Lupas for technical support. This work was supported by grants from the Public Health Service (AI-20980) and the American Cancer Society (NP-515). D.W. was supported by a postdoctoral fellowship from the National Cancer Institute. A.S. was supported by a postdoctoral fellowship from the Damon Runyon-Walter Winchell Cancer Fund.",

year = "1988",

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doi = "10.1016/S0006-291X(88)80365-6",

language = "English (US)",

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pages = "891--896",

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T1 - Sensory transduction in bacterial chemotaxis involves phosphotransfer between CHE proteins

AU - Wylie, David

AU - Stock, Ann

AU - Wong, Cing Yuen

AU - Stock, Jeff

N1 - Funding Information: We wish to thank Saul Roseman for his support and advice. We also thank Alex Ninfa and Boris Magasanik for information concerning the Ntr system. Finally we extend thanks to Katrina Forest, Tom Chen, Linda Han, and Andrei Lupas for technical support. This work was supported by grants from the Public Health Service (AI-20980) and the American Cancer Society (NP-515). D.W. was supported by a postdoctoral fellowship from the National Cancer Institute. A.S. was supported by a postdoctoral fellowship from the Damon Runyon-Walter Winchell Cancer Fund.

PY - 1988/3/15

Y1 - 1988/3/15

N2 - The CheA protein of the Salmonella typhimurium chemotaxis system is phosphorylated by ATP. Phospho-CheA transfers its phosphoryl group to a second chemotaxis protein, CheY. Unlike phospho-CheA, phospho-CheY is relatively unstable, rapidly decaying to phosphate and CheY. We propose that phosphorylation of CheY may play a role in its function as a tumble regulator to control motor behavior in response to attractant and repellent stimuli.

AB - The CheA protein of the Salmonella typhimurium chemotaxis system is phosphorylated by ATP. Phospho-CheA transfers its phosphoryl group to a second chemotaxis protein, CheY. Unlike phospho-CheA, phospho-CheY is relatively unstable, rapidly decaying to phosphate and CheY. We propose that phosphorylation of CheY may play a role in its function as a tumble regulator to control motor behavior in response to attractant and repellent stimuli.

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U2 - 10.1016/S0006-291X(88)80365-6

DO - 10.1016/S0006-291X(88)80365-6

M3 - Article

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AN - SCOPUS:0024287131

SN - 0006-291X

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EP - 896

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 2

ER -

Sensory transduction in bacterial chemotaxis involves phosphotransfer between CHE proteins

Abstract

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