TY - JOUR
T1 - Sensing external stress
T2 - Watchdogs of the Escherichia coli cell envelope
AU - Ruiz, Natividad
AU - Silhavy, Thomas J.
N1 - Funding Information:
We thank the members of the Silhavy laboratory, especially Susan DiRenzo for her assistance in the preparation of this manuscript. TJS is supported by grant GM34821 from the National Institute of General Medical Sciences.
PY - 2005/4
Y1 - 2005/4
N2 - The Cpx and σE signaling systems monitor the cell envelope in Escherichia coli. When induced, each system triggers a signaling cascade that leads to the upregulation of factors needed to combat envelope damage. Although each system is distinct and can be uniquely induced by certain cues, they also share striking similarities. In this review, we discuss the recent progress in our understanding of the Cpx and σE systems and compare how both function to maintain the integrity of the cell envelope.
AB - The Cpx and σE signaling systems monitor the cell envelope in Escherichia coli. When induced, each system triggers a signaling cascade that leads to the upregulation of factors needed to combat envelope damage. Although each system is distinct and can be uniquely induced by certain cues, they also share striking similarities. In this review, we discuss the recent progress in our understanding of the Cpx and σE systems and compare how both function to maintain the integrity of the cell envelope.
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U2 - 10.1016/j.mib.2005.02.013
DO - 10.1016/j.mib.2005.02.013
M3 - Review article
C2 - 15802241
AN - SCOPUS:15744389448
SN - 1369-5274
VL - 8
SP - 122
EP - 126
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
IS - 2
ER -