Semisynthetic proteins in mechanistic studies: using chemistry to go where nature can't

Jean Philippe Pellois, Tom W. Muir

Research output: Contribution to journalReview article

43 Scopus citations

Abstract

The manipulation of the chemical structure of proteins beyond what is feasible with standard genetics, offers a powerful strategy to investigate protein mechanisms. By allowing the incorporation of biophysical probes, unnatural amino acids, and post-translational modifications in proteins, chemistry-driven approaches have greatly contributed to the understanding of the molecular basis of protein function.

Original languageEnglish (US)
Pages (from-to)487-491
Number of pages5
JournalCurrent Opinion in Chemical Biology
Volume10
Issue number5
DOIs
StatePublished - Oct 1 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry

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