TY - JOUR
T1 - Semisynthetic proteins in mechanistic studies
T2 - using chemistry to go where nature can't
AU - Pellois, Jean Philippe
AU - Muir, Tom W.
N1 - Funding Information:
The authors acknowledge the support of the National Institutes of Health.
PY - 2006/10
Y1 - 2006/10
N2 - The manipulation of the chemical structure of proteins beyond what is feasible with standard genetics, offers a powerful strategy to investigate protein mechanisms. By allowing the incorporation of biophysical probes, unnatural amino acids, and post-translational modifications in proteins, chemistry-driven approaches have greatly contributed to the understanding of the molecular basis of protein function.
AB - The manipulation of the chemical structure of proteins beyond what is feasible with standard genetics, offers a powerful strategy to investigate protein mechanisms. By allowing the incorporation of biophysical probes, unnatural amino acids, and post-translational modifications in proteins, chemistry-driven approaches have greatly contributed to the understanding of the molecular basis of protein function.
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U2 - 10.1016/j.cbpa.2006.08.016
DO - 10.1016/j.cbpa.2006.08.016
M3 - Review article
C2 - 16935551
AN - SCOPUS:33748552028
SN - 1367-5931
VL - 10
SP - 487
EP - 491
JO - Current Opinion in Chemical Biology
JF - Current Opinion in Chemical Biology
IS - 5
ER -