Semisynthesis of a functional K+ channel

Francis I. Valiyaveetil; Matthew Sekedat; Tom W. Muir; Roderick MacKinnon

doi:10.1002/anie.200453849

Semisynthesis of a functional K⁺ channel

Francis I. Valiyaveetil
, Matthew Sekedat
, Tom W. Muir
, Roderick MacKinnon

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Selective ion-conduction properties in lipid membranes have been found for a semisynthetic KcsA K⁺ channel containing a mutation (A98G) that allows the channel to open. Thus, it is now possible to study ion conduction in a K⁺ channel with chemical modification of the main-chain atoms of the selectivity filter. The picture shows the single-channel responses of the semisynthetic K⁺ channel and its structure.

Original language	English (US)
Pages (from-to)	2504-2507
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	43
Issue number	19
DOIs	https://doi.org/10.1002/anie.200453849
State	Published - May 3 2004
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Chemistry
Catalysis

Keywords

Ion channels
Peptides
Potassium
Protein engineering

Access to Document

10.1002/anie.200453849

Cite this

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AU - Sekedat, Matthew

AU - Muir, Tom W.

AU - MacKinnon, Roderick

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KW - Ion channels

KW - Peptides

KW - Potassium

KW - Protein engineering

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