Abstract
Selective ion-conduction properties in lipid membranes have been found for a semisynthetic KcsA K+ channel containing a mutation (A98G) that allows the channel to open. Thus, it is now possible to study ion conduction in a K+ channel with chemical modification of the main-chain atoms of the selectivity filter. The picture shows the single-channel responses of the semisynthetic K+ channel and its structure.
Original language | English (US) |
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Pages (from-to) | 2504-2507 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 43 |
Issue number | 19 |
DOIs | |
State | Published - May 3 2004 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- General Chemistry
- Catalysis
Keywords
- Ion channels
- Peptides
- Potassium
- Protein engineering