Semisynthesis of a functional K+ channel

Francis I. Valiyaveetil, Matthew Sekedat, Tom W. Muir, Roderick MacKinnon

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


Selective ion-conduction properties in lipid membranes have been found for a semisynthetic KcsA K+ channel containing a mutation (A98G) that allows the channel to open. Thus, it is now possible to study ion conduction in a K+ channel with chemical modification of the main-chain atoms of the selectivity filter. The picture shows the single-channel responses of the semisynthetic K+ channel and its structure.

Original languageEnglish (US)
Pages (from-to)2504-2507
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number19
StatePublished - May 3 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Catalysis


  • Ion channels
  • Peptides
  • Potassium
  • Protein engineering


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