Selective ion-conduction properties in lipid membranes have been found for a semisynthetic KcsA K+ channel containing a mutation (A98G) that allows the channel to open. Thus, it is now possible to study ion conduction in a K+ channel with chemical modification of the main-chain atoms of the selectivity filter. The picture shows the single-channel responses of the semisynthetic K+ channel and its structure.
|Original language||English (US)|
|Number of pages||4|
|Journal||Angewandte Chemie - International Edition|
|State||Published - May 3 2004|
All Science Journal Classification (ASJC) codes
- Ion channels
- Protein engineering