Self-sorting of white blood cells in a lattice

Robert H. Carlson, Christopher V. Gabel, Shirley S. Chan, Robert H. Austin, James P. Brody, James W. Winkelman

Research output: Contribution to journalArticlepeer-review

97 Scopus citations

Abstract

When a drop of human blood containing red and white blood cells is forced to move via hydrodynamic forces in a lattice of channels designed to mimic the capillary channels, the white cells self-fractionate into the different types of white cells. The pattern of white cells that forms is due to a combination of stretch-activated adhesion of cells with the walls, stochastic sticking probabilities, and heteroavoidance between granulocytes and lymphocytes.

Original languageEnglish (US)
Pages (from-to)2149-2152
Number of pages4
JournalPhysical review letters
Volume79
Issue number11
DOIs
StatePublished - Sep 15 1997

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

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