Morphogen gradients are concentration fields of molecules acting as spatial regulators of cell differentiation in developing tissues and play a fundamental role in various aspects of embryonic development. We discovered a family of self-similar solutions in a canonical class of nonlinear reaction-diffusion models describing the formation of morphogen gradients. These solutions are realized in the limit of infinitely high production rate at the tissue boundary and are given by the product of the steady state concentration profile and a function of the diffusion similarity variable. We solved the boundary value problem for the similarity profile numerically and analyzed the implications of the discovered self-similarity on the dynamics of morphogenetic patterning.
|Original language||English (US)|
|Journal||Physical Review E - Statistical, Nonlinear, and Soft Matter Physics|
|State||Published - Oct 14 2011|
All Science Journal Classification (ASJC) codes
- Statistical and Nonlinear Physics
- Statistics and Probability
- Condensed Matter Physics