Self-assembling enzymes and the origins of the cytoskeleton

Rachael M. Barry, Zemer Gitai

Research output: Contribution to journalReview article

33 Scopus citations

Abstract

The bacterial cytoskeleton is composed of a complex and diverse group of proteins that self-assemble into linear filaments. These filaments support and organize cellular architecture and provide a dynamic network controlling transport and localization within the cell. Here, we review recent discoveries related to a newly appreciated class of self-assembling proteins that expand our view of the bacterial cytoskeleton and provide potential explanations for its evolutionary origins. Specifically, several types of metabolic enzymes can form structures similar to established cytoskeletal filaments and, in some cases, these structures have been repurposed for structural uses independent of their normal roles. The behaviors of these enzymes suggest that some modern cytoskeletal proteins may have evolved from dual-role proteins with catalytic and structural functions.

Original languageEnglish (US)
Pages (from-to)704-711
Number of pages8
JournalCurrent opinion in microbiology
Volume14
Issue number6
DOIs
StatePublished - Dec 1 2011

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Self-assembling enzymes and the origins of the cytoskeleton'. Together they form a unique fingerprint.

  • Cite this