Selective Neuronal Vulnerability in Alzheimer's Disease: A Network-Based Analysis

Jean Pierre Roussarie; Vicky Yao; Patricia Rodriguez-Rodriguez; Rose Oughtred; Jennifer Rust; Zakary Plautz; Shirin Kasturia; Christian Albornoz; Wei Wang; Eric F. Schmidt; Ruth Dannenfelser; Alicja Tadych; Lars Brichta; Alona Barnea-Cramer; Nathaniel Heintz; Patrick R. Hof; Myriam Heiman; Kara Dolinski; Marc Flajolet; Olga G. Troyanskaya; Paul Greengard

doi:10.1016/j.neuron.2020.06.010

Selective Neuronal Vulnerability in Alzheimer's Disease: A Network-Based Analysis

Jean Pierre Roussarie
, Vicky Yao
, Patricia Rodriguez-Rodriguez
, Rose Oughtred
, Jennifer Rust
, Zakary Plautz
, Shirin Kasturia
, Christian Albornoz
, Wei Wang
, Eric F. Schmidt
, Ruth Dannenfelser
, Alicja Tadych
, Lars Brichta
, Alona Barnea-Cramer
, Nathaniel Heintz
, Patrick R. Hof
, Myriam Heiman
, Kara Dolinski
, Marc Flajolet
, Olga G. Troyanskaya

Paul Greengard

Research output: Contribution to journal › Article › peer-review

136 Scopus citations

Abstract

Neurons display different levels of vulnerability to Alzheimer's pathology. Roussarie et al. experimentally profile and computationally model several relevant neuron types. Using a mouse-human framework, they identify genes linking Aß, aging, and tau in vulnerable neurons. Finally, they show experimentally that PTB, a regulator of tau splicing, contributes to vulnerability.

Original language	English (US)
Pages (from-to)	821-835.e12
Journal	Neuron
Volume	107
Issue number	5
DOIs	https://doi.org/10.1016/j.neuron.2020.06.010
State	Published - Sep 9 2020

All Science Journal Classification (ASJC) codes

General Neuroscience

Keywords

Alzheimer's disease
PTBP1
bacTRAP
machine learning
network
selective neuronal vulnerability

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10.1016/j.neuron.2020.06.010

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Roussarie, J. P., Yao, V., Rodriguez-Rodriguez, P., Oughtred, R., Rust, J., Plautz, Z., Kasturia, S., Albornoz, C., Wang, W., Schmidt, E. F., Dannenfelser, R., Tadych, A., Brichta, L., Barnea-Cramer, A., Heintz, N., Hof, P. R., Heiman, M., Dolinski, K., Flajolet, M., ... Greengard, P. (2020). Selective Neuronal Vulnerability in Alzheimer's Disease: A Network-Based Analysis. Neuron, 107(5), 821-835.e12. https://doi.org/10.1016/j.neuron.2020.06.010

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title = "Selective Neuronal Vulnerability in Alzheimer's Disease: A Network-Based Analysis",

abstract = "Neurons display different levels of vulnerability to Alzheimer's pathology. Roussarie et al. experimentally profile and computationally model several relevant neuron types. Using a mouse-human framework, they identify genes linking A{\ss}, aging, and tau in vulnerable neurons. Finally, they show experimentally that PTB, a regulator of tau splicing, contributes to vulnerability.",

keywords = "Alzheimer's disease, PTBP1, bacTRAP, machine learning, network, selective neuronal vulnerability",

author = "Roussarie, \{Jean Pierre\} and Vicky Yao and Patricia Rodriguez-Rodriguez and Rose Oughtred and Jennifer Rust and Zakary Plautz and Shirin Kasturia and Christian Albornoz and Wei Wang and Schmidt, \{Eric F.\} and Ruth Dannenfelser and Alicja Tadych and Lars Brichta and Alona Barnea-Cramer and Nathaniel Heintz and Hof, \{Patrick R.\} and Myriam Heiman and Kara Dolinski and Marc Flajolet and Troyanskaya, \{Olga G.\} and Paul Greengard",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2020",

month = sep,

day = "9",

doi = "10.1016/j.neuron.2020.06.010",

language = "English (US)",

volume = "107",

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Roussarie, JP, Yao, V, Rodriguez-Rodriguez, P, Oughtred, R, Rust, J, Plautz, Z, Kasturia, S, Albornoz, C, Wang, W, Schmidt, EF, Dannenfelser, R, Tadych, A, Brichta, L, Barnea-Cramer, A, Heintz, N, Hof, PR, Heiman, M, Dolinski, K, Flajolet, M, Troyanskaya, OG & Greengard, P 2020, 'Selective Neuronal Vulnerability in Alzheimer's Disease: A Network-Based Analysis', Neuron, vol. 107, no. 5, pp. 821-835.e12. https://doi.org/10.1016/j.neuron.2020.06.010

TY - JOUR

T1 - Selective Neuronal Vulnerability in Alzheimer's Disease

T2 - A Network-Based Analysis

AU - Roussarie, Jean Pierre

AU - Yao, Vicky

AU - Rodriguez-Rodriguez, Patricia

AU - Oughtred, Rose

AU - Rust, Jennifer

AU - Plautz, Zakary

AU - Kasturia, Shirin

AU - Albornoz, Christian

AU - Wang, Wei

AU - Schmidt, Eric F.

AU - Dannenfelser, Ruth

AU - Tadych, Alicja

AU - Brichta, Lars

AU - Barnea-Cramer, Alona

AU - Heintz, Nathaniel

AU - Hof, Patrick R.

AU - Heiman, Myriam

AU - Dolinski, Kara

AU - Flajolet, Marc

AU - Troyanskaya, Olga G.

AU - Greengard, Paul

PY - 2020/9/9

Y1 - 2020/9/9

N2 - Neurons display different levels of vulnerability to Alzheimer's pathology. Roussarie et al. experimentally profile and computationally model several relevant neuron types. Using a mouse-human framework, they identify genes linking Aß, aging, and tau in vulnerable neurons. Finally, they show experimentally that PTB, a regulator of tau splicing, contributes to vulnerability.

AB - Neurons display different levels of vulnerability to Alzheimer's pathology. Roussarie et al. experimentally profile and computationally model several relevant neuron types. Using a mouse-human framework, they identify genes linking Aß, aging, and tau in vulnerable neurons. Finally, they show experimentally that PTB, a regulator of tau splicing, contributes to vulnerability.

KW - Alzheimer's disease

KW - PTBP1

KW - bacTRAP

KW - machine learning

KW - network

KW - selective neuronal vulnerability

UR - https://www.scopus.com/pages/publications/85087931939

UR - https://www.scopus.com/pages/publications/85087931939#tab=citedBy

U2 - 10.1016/j.neuron.2020.06.010

DO - 10.1016/j.neuron.2020.06.010

M3 - Article

C2 - 32603655

AN - SCOPUS:85087931939

SN - 0896-6273

VL - 107

SP - 821-835.e12

JO - Neuron

JF - Neuron

IS - 5

ER -

Selective Neuronal Vulnerability in Alzheimer's Disease: A Network-Based Analysis

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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