TY - JOUR
T1 - Selective Neuronal Vulnerability in Alzheimer's Disease
T2 - A Network-Based Analysis
AU - Roussarie, Jean Pierre
AU - Yao, Vicky
AU - Rodriguez-Rodriguez, Patricia
AU - Oughtred, Rose
AU - Rust, Jennifer
AU - Plautz, Zakary
AU - Kasturia, Shirin
AU - Albornoz, Christian
AU - Wang, Wei
AU - Schmidt, Eric F.
AU - Dannenfelser, Ruth
AU - Tadych, Alicja
AU - Brichta, Lars
AU - Barnea-Cramer, Alona
AU - Heintz, Nathaniel
AU - Hof, Patrick R.
AU - Heiman, Myriam
AU - Dolinski, Kara
AU - Flajolet, Marc
AU - Troyanskaya, Olga G.
AU - Greengard, Paul
N1 - Publisher Copyright:
© 2020 The Authors
PY - 2020/9/9
Y1 - 2020/9/9
N2 - Neurons display different levels of vulnerability to Alzheimer's pathology. Roussarie et al. experimentally profile and computationally model several relevant neuron types. Using a mouse-human framework, they identify genes linking Aß, aging, and tau in vulnerable neurons. Finally, they show experimentally that PTB, a regulator of tau splicing, contributes to vulnerability.
AB - Neurons display different levels of vulnerability to Alzheimer's pathology. Roussarie et al. experimentally profile and computationally model several relevant neuron types. Using a mouse-human framework, they identify genes linking Aß, aging, and tau in vulnerable neurons. Finally, they show experimentally that PTB, a regulator of tau splicing, contributes to vulnerability.
KW - Alzheimer's disease
KW - PTBP1
KW - bacTRAP
KW - machine learning
KW - network
KW - selective neuronal vulnerability
UR - http://www.scopus.com/inward/record.url?scp=85087931939&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85087931939&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2020.06.010
DO - 10.1016/j.neuron.2020.06.010
M3 - Article
C2 - 32603655
AN - SCOPUS:85087931939
SN - 0896-6273
VL - 107
SP - 821-835.e12
JO - Neuron
JF - Neuron
IS - 5
ER -