Segregating variation in the transcriptome: Cis regulation and additivity of effects

Kimberly A. Hughes, Julien F. Ayroles, Melissa M. Reedy, Jenny M. Drnevich, Kevin C. Rowe, Elizabeth A. Ruedi, Carla E. Cáceres, Ken N. Paige

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Properties of genes underlying variation in complex traits are largely unknown, especially for variation that segregates within populations. Here, we evaluate allelic effects, cis and trans regulation, and dominance patterns of transcripts that are genetically variable in a natural population of Drosophila melanogaster. Our results indicate that genetic variation due to the third chromosome causes mainly additive and nearly additive effects on gene expression, that cis and trans effects on gene expression are numerically about equal, and that cis effects account for more genetic variation than do trans effects. We also evaluated patterns of variation in different functional categories and determined that genes involved in metabolic processes are overrepresented among variable transcripts, but those involved in development, transcription regulation, and signal transduction are underrepresented. However, transcripts for proteins known to be involved in protein-protein interactions are proportionally represented among variable transcripts.

Original languageEnglish (US)
Pages (from-to)1347-1355
Number of pages9
JournalGenetics
Volume173
Issue number3
DOIs
StatePublished - 2006

All Science Journal Classification (ASJC) codes

  • Genetics

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    Hughes, K. A., Ayroles, J. F., Reedy, M. M., Drnevich, J. M., Rowe, K. C., Ruedi, E. A., Cáceres, C. E., & Paige, K. N. (2006). Segregating variation in the transcriptome: Cis regulation and additivity of effects. Genetics, 173(3), 1347-1355. https://doi.org/10.1534/genetics.105.051474